International Journal of Endocrinology

Review Article

Clinical Characteristics of 76 Patients with IgG4-Related Hypophysitis: A Systematic Literature Review

Table 2

Summary of the reported cases of IgG4-related hypophysitis.
Case noAgeSexIgG4 (mg/dl)Pituitary functionMRINumber of other affected organsBiopsyTherapyResponseAuthors
AHDIStalkPituitaryPituitaryOthersSymptomMRI
166F485+−−+4−—GC++van der Vliet [3]
271M405++−+3−Submandibular gland, retroperitoneumGC++Tanabe et al. [8]
370M2220+−+−2−Submandibular glandGC++Yamamoto et al. [9]
477M720+−−+2+Pancreas, cholecystSurgery + GCndndWong et al. [5]
555M1860+++−2−Paranasal sinusGC++Isaka et al. [10]
662M292+++−3−LungGC++Tsuboi et al. [11]
774Fnd++++1+—Surgery + GC++Osawa et al. [12]
870M924+++−3−Liver, lung, parotid glandGC++Hori et al. [14]
968M159nd+++2−—GC++Haraguchi et al. [13]
1074F170++++1−Lymph nodeGC++Haraguchi et al. [13]
1155M127++++3−Lacrimal gland, kidneyndndndPatel and Szostek [16]
1271M240−+++1−PleuralGCndndNagai et al. [15]
1375Mnd++++1+Paranasal sinusGC++Leporati et al. [6]
1447M94.9ndnd−+3+Lung, lymph nodeGC++Nishina et al. [17]
1553FNormal+−−+0+—Surgery + GC++Kanoke et al. [20]
1660FNormal+−++0+—Surgery + GC++Kanoke et al. [20]
1766Mnd+−+−4+MediastinumSurgery + GC++Hsing et al. [19]
1855M1010−−++0+—GC++Hattori et al. [18]
1953M24.5+++−3−LungGCnd+Bando et al. [21]
2076M513++++0−—GCnd+Bando et al. [21]
2158F405nd+++3−Lung, stomachGCnd+Bando et al. [21]
2268F16.9+−+−0+—GCnd+Bando et al. [21]
2353F16.9++++1+—GCnd+Bando et al. [21]
2467F82.5++++0+—GCnd+Bando et al. [21]
2576M2100++++2+PancreasGC++Iseda et al. [23]
2633Fnd+++−0+—Surgery + GC++Khong et al. [24]
2770M300++++3+RetroperitoneumGC++Ohkubo et al. [25]
2840M413++++1+Lacrimal glandGC + azathioprine++Caputo et al. [22]
2937Fnd++++0+—GC++Sosa et al. [26]
3025Fnd+−++0+—GC++Sosa et al. [26]
3171Mnd−+++0+—ndndndImber et al. [28]
3287M285++++0−—GC++Nakasone et al. [30]
3332Fnd++−+0+—GC  Tauziede-Espariat et al. [32]
3438FNormal++−+0+—GC++Tauziede-Espariat et al. [32]
3543M79.2+−++1+—GC+−Ngaosuwan et al. [31]
3667M240+++−2−LiverGC + azathioprine++Joshi et al. [29]
3762M307−+++2−KidneyGCndndJoshi et al. [29]
3872M853+++−1−KidneyGC++Harano et al. [27]
3938F377++−+2+OrbitaGC++Alexandraki et al. [33]
4055M800++++0+—GC++Bhagwat et al. [34]
4116Fnd−+++0+—GCndndDecker et al. [35]
4254Mnd++++2−KidneyGC++Patel et al. [36]
4376M1030+−++0+—GC++Anno et al. [37]
4457M83.9++++5+—GC + azathioprine+ndGu et al. [38]
4529F135++−+0+—Surgery + GC + MMF++Hadjigeorgiou et al. [39]
4656M570.7++++2−—Surgery + GC++Huang et al. [40]
4770M425+++−4−LipNo——Kawasaki et al. [41]
4851Fnd++++0+—Surgery + GC++Lee et al. [42]
4985M713nd++−1−KidneyGC++Matsuda et al. [43]
5036Fnd++++0+—Surgery + GC+ndRotondo et al. [44]
5149Mnd+−++0+—GC++Rotondo et al. [44]
5256M298+−++3−—GC++Yatabe et al. [45]
5314F61−−++0+—GC + rituximab−+Bullock et al. [46]
5425F55.7++++0+—GC++Koide et al. [48]
5523Fnd++−+1+RetroperitoneumSurgery + GCndndGuarda et al. [47]
5650M426++−+7+—GC−−Liu et al. [49]
5716F43.7+++−2−Submandibular glandGC−−Liu et al. [49]
5857F2250−++−3−Lacrimal glandGC++Liu et al. [49]
5936M2470−++−4−Lacrimal glandGC++Liu et al. [49]
6044M1910−++−3−PancreasGC++Liu et al. [49]
6146M327+++−1−Lymph nodeGC++Liu et al. [49]
6251M1980−++−3−Submandibular glandGC++Liu et al. [49]
6358M5410+++−4−—GC++Liu et al. [49]
6464M199++++0−—GC++Liu et al. [49]
6561M4680++++2−Paranasal sinusGC++Liu et al. [49]
6658F58++++0+—GC++Murphy et al. [50]
6736MNormal++++0+—GC++Sosa et al. [51]
6867F865nd++−6+BladderGC++Xue et al. [53]
6950M13.1ndnd−+0+—Surgery++Tang et al. [52]
7024FNormal++++0+—Surgery + GC++Yuen et al. [54]
7124FNormalndnd−+0+—GC+ndYuen et al. [54]
7271MNormal++−+0+—GC+−Yuen et al. [54]
7378M802+nd−+4−—Surgery + GC++Kanie et al. [56]
7443F462++++2−OrbitaGC++Yoshida et al. [58]
7528F880−−−+0−—Methotrexate + rituximab+ndGoulam-Houssein et al. [55]
7665M221+nd−+0+—Surgery + GC + rituximab++Vauchot et al. [57]
F, female; M, male; nd, not described; AH, anterior hypophysitis; DI, diabetes insipidus; GC, glucocorticoid; MMF, mycophenolate mofetil.