Comparative Proteome Analysis of Epicardial and Subcutaneous Adipose Tissues from Patients with or without Coronary Artery Disease

Table 2

Changes in differential expression of proteins involved in significant biological functions and signal pathways from EAT and SAT between CAD and non-CAD subjects.

	Differential proteins from EAT (CAD vs non-CAD)	Numbers	Differential proteins from SAT (CAD vs non-CAD)	Numbers
Biological function
Metabolic disorder
Up	CA1, CA2, CA3, F2, ITGB3, THBS1	6	LPA	1
Down	ATP2A2, FABP4, FABP5, FASN, LIPE, PDE3B	6	APOA2	1
Inflammatory response
Up	BPI, C3, CAMP, CORO1A, CTSG, CYBB, DEFA1, HCK, IL16, ITGAM, ITGB2, LPA, MMP9, NCKAP1L, ORM1, PROS1, RELA, S100A12, S100A8, SERPINA3, THBS1, THBS4	22	APOL3/APOL4, LPA	2
Down		0	AGT, BPI, HCK, ITGB2, KNG1, S100A12, S100A9, SERPINA1	8
Lipid metabolism
Up	ALOX5, ATP8A1, CLU, F2, IL16, ITGB3, LTF, MECR, RELA, VTN	10		0
Down	ACOT1, AKR1C1/AKR1C2, AKR1C3, APOA2, FASN, PLTP, SDHA, SUCLA2	8	AGT, ALOX5, KNG1, SOD-1	4
cell-to-cell signaling and interaction
Up	A2M, C3, C4B, CORO1A, CTSG, ELANE, F10, F2, FCGR3B, FERMT3, FGA, FN1, ICAM3, ITGA2B, ITGAM, ITGB1, ITGB2, LTF, ORM1, RELA, S100A8, SLC4A1, THBS1, ITGB3, VTN, BPI, F5, DEFA1, ASAP2, CAMP, HCK, PROS1, PRTN3	33	FN1	1
Down	PLTP, FERMT2, RRAS2	3	BPI, ITGB1, ITGB2, KNG1, S100A9, BGN, S100A12, AGT	8
free radial Scavenging
Up	ALOX5, CAMP, CYBB, ELANE, F2, FCGR3B, HBB, HTT, IMMT, ITGAM, ITGB1, ITGB2, ITGB3, LTF, MPO, NGFR, PRTN3, PTPN6	18	FTL	1
Down	CRYAB	1	AGT, ALOX5, HBB, HTT, IMMT, ITGB1, ITGB2, MPOSEPP1, SERPINA1, SOD1	11
Signal pathway
LXR/RXR signal pathway
Up	FGA, MMP9, CLU, SERPINF2, ORM1, NGFR, C4B, S100A8, RELA, TTR, LPA, C3, VTN	13	FDFT1, LPA	2
Down	APOA2, PCYOX1, FDFT1, FASN, PLTP, HADH	6	APOL1, KNG1, PON1, TF, APOA2, C4B,; SERPINA1, AGT	8
Acute phase response
Up	RELA, ITIH3, TTR, C4BPB, FN1, C3, C1S, SERPINA3, F2, SERPINF2, FGG, SERPI-ND1, ORM1, C4BPA, NGFR, C4B, FGB, FGA, A2M	19	FTL, FN1, FGG	3
Down	APOA2, RRAS2	2	TF, APOA2, C4B, SERPINA1, AGT	5
Mitochondrial dysfunction
Up	SNCA	1	ATP5J, ATPAF2	2
Down	NDUFA4, SDHA, ATP5J, NDUFV1, ATP5A1, UQCRB, MT-CO2, MAOB, NDUFA6, UQCRC2, NDUFA10, CYB5A, ATPAF2, OGDH, UQCRC1, ATP5F1, M-AOA, NDUFS4	18	NDUFV2, NDUFS6, NDUFA8	3