International Journal of Endocrinology / 2019 / Article / Tab 2

Research Article

Comparative Proteome Analysis of Epicardial and Subcutaneous Adipose Tissues from Patients with or without Coronary Artery Disease

Table 2

Changes in differential expression of proteins involved in significant biological functions and signal pathways from EAT and SAT between CAD and non-CAD subjects.

Differential proteins from EAT (CAD vs non-CAD)NumbersDifferential proteins from SAT (CAD vs non-CAD)Numbers

Biological function
Metabolic disorder
 UpCA1, CA2, CA3, F2, ITGB3, THBS16LPA1
 DownATP2A2, FABP4, FABP5, FASN, LIPE, PDE3B6APOA21
Inflammatory response
 UpBPI, C3, CAMP, CORO1A, CTSG, CYBB, DEFA1, HCK, IL16, ITGAM, ITGB2, LPA, MMP9, NCKAP1L, ORM1, PROS1, RELA, S100A12, S100A8, SERPINA3, THBS1, THBS422APOL3/APOL4, LPA2
 Down0AGT, BPI, HCK, ITGB2, KNG1, S100A12, S100A9, SERPINA18
Lipid metabolism
 UpALOX5, ATP8A1, CLU, F2, IL16, ITGB3, LTF, MECR, RELA, VTN100
 DownACOT1, AKR1C1/AKR1C2, AKR1C3, APOA2, FASN, PLTP, SDHA, SUCLA28AGT, ALOX5, KNG1, SOD-14
cell-to-cell signaling and interaction
 UpA2M, C3, C4B, CORO1A, CTSG, ELANE, F10, F2, FCGR3B, FERMT3, FGA, FN1, ICAM3, ITGA2B, ITGAM, ITGB1, ITGB2, LTF, ORM1, RELA, S100A8, SLC4A1, THBS1, ITGB3, VTN, BPI, F5, DEFA1, ASAP2, CAMP, HCK, PROS1, PRTN333FN11
 DownPLTP, FERMT2, RRAS23BPI, ITGB1, ITGB2, KNG1, S100A9, BGN, S100A12, AGT8
free radial Scavenging
 UpALOX5, CAMP, CYBB, ELANE, F2, FCGR3B, HBB, HTT, IMMT, ITGAM, ITGB1, ITGB2, ITGB3, LTF, MPO, NGFR, PRTN3, PTPN618FTL1
 DownCRYAB1AGT, ALOX5, HBB, HTT, IMMT, ITGB1, ITGB2, MPOSEPP1, SERPINA1, SOD111

Signal pathway
LXR/RXR signal pathway
 UpFGA, MMP9, CLU, SERPINF2, ORM1, NGFR, C4B, S100A8, RELA, TTR, LPA, C3, VTN13FDFT1, LPA2
 DownAPOA2, PCYOX1, FDFT1, FASN, PLTP, HADH6APOL1, KNG1, PON1, TF, APOA2, C4B,
SERPINA1, AGT
8
Acute phase response
 UpRELA, ITIH3, TTR, C4BPB, FN1, C3, C1S, SERPINA3, F2, SERPINF2, FGG, SERPI-ND1, ORM1, C4BPA, NGFR, C4B, FGB, FGA, A2M19FTL, FN1, FGG3
 DownAPOA2, RRAS22TF, APOA2, C4B, SERPINA1, AGT5
Mitochondrial dysfunction
 UpSNCA1ATP5J, ATPAF22
 DownNDUFA4, SDHA, ATP5J, NDUFV1, ATP5A1, UQCRB, MT-CO2, MAOB, NDUFA6, UQCRC2, NDUFA10, CYB5A, ATPAF2, OGDH, UQCRC1, ATP5F1, M-AOA, NDUFS418NDUFV2, NDUFS6, NDUFA83

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.