Research Article
The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population
Table 4
Comparison of clinical and biological profiles between seropositive and seronegative patients.
| | | Seropositive group, n (%) | Seronegative group, n (%) | value |
| | Clinical manifestations | | | | | Pallor | 8 (32%) | 23 (9.2%) | 0.003 | | Chronic constipation | 14 (56%) | 69 (27.5%) | 0.003 | | Abdominal pain | 18 (72%) | 94 (37.8%) | 0.001 | | Bloating | 16 (64%) | 77 (30.7%) | 0.001 | | Recent weight loss | 17 (68%) | 114 (45.4%) | 0.031 | | Diarrhea | 9 (36%) | 54 (21.9%) | 0.111 | | Nausea and vomiting | 4 (16%) | 31 (12.7%) | 0.416 | | Chronic fatigue | 13 (52%) | 92 (36.7%) | 0.132 | | Lack of appetite | 9 (36%) | 70 (27.9%) | 0.392 | | Other associated AIDs | 4 (16%) | 6 (2.4%) | 0.008 | | Median Z scores of height | −0.90 (−3.93 _ 0.95) | −0.51 (−4.54 _ 2.18) | 0.029 | | Median Z scores of BMI | −0.07 (−2.50 _ 1.24) | −0.04 (−4.87 _ 3.43) | 0.880 | | Median HbA1c | 11.30 (7.31_16.00) | 9.30 (4.40 _ 17.31) | 0.022 | | T1D-tested auto-antibodies | | | | | GAD65-ab (%) | (13) 52% | (104) 41.4% | 0.308 | | GAD65-ab mean titers (UI/ml) | 231.1 (33.15–500) | 184.2 (30.02–500) | 0.096 | | Anti-insulin-ab (%) | (7) 28% | (81) 32.3% | 0.662 | | Anti-insulin-ab mean titers (UI/ml) | 83.49 (18.04–300) | 47.99 (18.24–300) | 0.603 | | IA2-ab (%) | (11) 44% | (67) 26.7% | 0.067 | | IA2-ab mean titers (UI/ml) | 109.8 (30.85–370.5) | 176.54 (30.29–500) | 0.064 | | ZnT8-ab (%) | (11) 44% | (89) 35.5% | 0.397 | | ZnT8-ab mean titers (UI/ml) | 170.77 (16–47–500) | 194.43 (15.10–500) | 0.002 | | Overall positivity (%) | (23) 92% | (197) 78.5% | 0.109 |
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AID: autoimmune diseases; BMI: body mass index. Statistically significant differences. |
