International Journal of Endocrinology / 2019 / Article / Tab 1

Research Article

Decreased Serum microRNA-21, microRNA-25, microRNA-146a, and microRNA-181a in Autoimmune Diabetes: Potential Biomarkers for Diagnosis and Possible Involvement in Pathogenesis

Table 1

Clinical characteristics of study population.

T1D (n = 29)LADA (n = 16)T2D (n = 31)Nondiabetic individuals (n = 19)

Sex (male/female)10/1910/619/1215/4
Age (years)24.0 ± 9.1abc51.9 ± 9.5ad44.9 ± 7.7ad30.3 ± 5.0abc
Age of onset (years)20.8 ± 10.0bc46.3 ± 8.7a41.7 ± 6.5aN/A
Duration (years)3.4 ± 4.25.6 ± 5.03.2 ± 2.4N/A
BMI (kg/m2)21.1 ± 3.921.9 ± 2.723.1 ± 2.623.2 ± 2.9
HbA1c (%)8.7 ± 2.3d8.4 ± 1.5cd7.2 ± 1.8bd5.1 ± 0.2abc
FCP (ng/dL)0.46 ± 0.63cd0.16 ± 0.20cd0.63 ± 0.56ab1.24 ± 0.31ab
2hCP (ng/dL)1.16 ± 1.86cd0.35 ± 0.49cd5.02 ± 2.79ab3.72 ± 1.24ab
TC (mmol/L)4.80 ± 1.69c4.56 ± 1.19c5.53 ± 0.91abd5.00 ± 1.35c
TG (mmol/L)1.10 ± 0.830.82 ± 0.65c1.82 ± 1.15bd1.10 ± 0.64c
HDL-C (mmol/L)1.43 ± 0.401.51 ± 0.471.20 ± 0.231.34 ± 0.27
LDL-C (mmol/L)2.78 ± 1.352.45 ± 0.793.10 ± 0.68d2.46 ± 1.08c
GAD titers (IU/mL)260.8 ± 457.0bcd354.7 ± 363.1acd0ab0ab
IA-2A titers (IU/mL)688.8 ± 1322.5bcd288.6 ± 995.0bcd0ab0ab
ICA titers (IU/mL)6.9 ± 10.0cd5.0 ± 6.3cd0ab0ab

Note: a, compared with T1D, ; b, compared with LADA, ; c, compared with T2D, ; d, compared with nondiabetic individuals, . Abbreviations: T1D, type 1 diabetes; LADA, latent autoimmune diabetes of adults; T2D, type 2 diabetes; BMI, body mass index; HbA1c, glycosylated hemoglobin; FCP, fasting C-peptide; 2hCP, 2-h postprandial C-peptide; TC, total cholesterol; TG, total triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; GADA, glutamic acid decarboxylase antibody; IA-2A, protein tyrosine phosphatase antibody; ICA, islet cell antibody.

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