Decreased Serum microRNA-21, microRNA-25, microRNA-146a, and microRNA-181a in Autoimmune Diabetes: Potential Biomarkers for Diagnosis and Possible Involvement in Pathogenesis

Table 2

Association of serum levels of miR-21, miR-25, miR-146a, and miR-181a with clinical parameters in autoimmune diabetes.

	miR-21	miR-25	miR-146a	miR-181a
Sex	0.024	−0.231	−0.150	0.064
Age	0.269	0.576	0.260	0.016
BMI	−0.069	0.296	0.046	−0.151
Age of onset	0.192	0.483	0.249	−0.026
Duration	0.156	0.265	−0.025	−0.100
HbA1c	0.079	−0.115	0.147	0.175
FCP	−0.106	−0.284	0.011	0.079
2hCP	−0.173	−0.132	−0.006	0.045
TC	0.021	−0.159	0.059	−0.020
TG	−0.093	−0.315	0.009	−0.100
HDL-C	0.209	−0.034	0.026	−0.095
LDL-C	−0.018	−0.239	0.020	0.053
GADA titers	0.006	−0.069	0.235	0.039
ICA titers	−0.028	−0.152	−0.083	0.118
IA-2A titers	−0.181	−0.224	−0.077	0.116
Number of positive antibodies	0.157	−0.058	0.125	0.166

Note: ; . Abbreviations: T1D, type 1 diabetes; LADA, latent autoimmune diabetes of adults; T2D, type 2 diabetes; BMI, body mass index; HbA1c, glycosylated hemoglobin; FCP, fasting C-peptide; 2hCP, 2-h postprandial C-peptide; TC, total cholesterol; TG, total triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; GADA, glutamic acid decarboxylase antibody; IA-2A, protein tyrosine phosphatase antibody; ICA, islet cell antibody.