Identification of Serum miRNA-423-5p Expression Signature in Somatotroph Adenomas

Table 2

Univariate and multivariate analyses for the clinicopathological correlates.

variables	Aggressiveness		univariate analysis
	Yes(n=24)	No(n=38)		p-value
age (years)
≤37.6	13	18	0.272	0.602
>37.6	11	20
gender
Male	14	17	1.088	0.297
Female	10	21
Tumor size(cm^3)
≤9.85	17	14	6.798	0.009
>9.85	7	24
Preoperative serum
GH level(ng/ml)
≤26.5	16	15	4.351	0.037
>26.5	8	23
PTTG1
High	18	13	19.789	0.002
Low	6	25
SYT1
High	16	15	4.351	0.037
Low	8	23

GH: growth hormone
High: The positive percent of PTTG1 or SYT1 is equal or more than 50%. Low: The nuclear-positive percent of PTTG1 or SYT1 is less than 50%.