Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes
Table 2
Characteristics of all type 2 diabetic patients by chemerin tertiles.
First tertile
Second tertile
Third tertile
≤80ng/ml
80-120ng/ml
≥120ng/ml
P
Number (n)
113
246
239
Age (years)
54.07(11.99)
54.27(11.89)
55.08(12.48)
NS
Sex (male/female)
76/37
165/81
142/97
NS
Duration of diabetes (years)△
5(2,11)
7(3,12)∗
9 (4,15)∗#
<0.001
Waist circumference (cm)
85.15(8.80)
87.25(8.92)
88.28(10.02)
NS
BMI (kg/m2)
24.35(3.96)
25.31(3.09)∗
25.94(3.60)∗#
<0.001
SBP (mmHg)
126.18(13.74)
124.02(13.92)
130.59(14.90)∗#
<0.001
DBP (mmHg)
79.09(6.65)
78.96(6.75)
79.169(6.48)
NS
Glycated hemoglobin (%)
8.59(1.72)
8.61(1.85)
8.88(1.94)
NS
Triglycerides (mmol/l) △
1.70(1.24,2.59)
1.54(1.03,2.50)
1.7 (1.21,2.76)
NS
Total cholesterol (mmol/l)
4.74(1.00)
4.64(1.08)
4.88(1.07)
NS
HDL cholesterol (mmol/l)
1.12(0.33)
1.10(0.29)
1.08(0.36)
NS
LDL cholesterol (mmol/l)
2.70(0.86)
2.79(0.85)
2.89(0.78)
NS
Scr (umol/l)
54.876(17.38)
57.22(16.37)
69.55(28.50)∗#
<0.001
UAE (mg/24h)△
15.0(9.7,32.43)
17.11(11.8,41.61)
75.22(16.2,371.45)∗#
<0.001
hs-CRP (mg/L) △
3.2(1.2,7.1)
4.5(1.77,8.94)∗
5.80(2.3,10.6)∗#
<0.001
Medication
Oral hypoglycemic agents
22(21.2%)
67(27.2%)
48(20.1%)
NS
Insulin
64(78.8%)
165(72.8%)
162(70.9%)
NS
Hypertension (%)
63(55.8%)
135(54.9%)
166(69.4%)∗#
<0.001
Numerical variables are expressed as the mean with SD and median (interquartile range). Categorical variables were presented as number (percentage). P-value for difference between the groups was calculated from the analysis of one-way ANOVA, ∗vs. First tertile group, and # vs. Second tertile. BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; Scr, serum creatinine; UAE, urinary albumin excretion; hs-CRP, high sensitivity C-reactive protein; NS, not significant; UAE, urinary albumin excretion. △Natural logarithmic transformation was used in analysis.
