A Novel Pentapeptide Inhibitor Reduces Amyloid Deposit Formation by Direct Interaction with hIAPP

Figure 1

Molecular docking simulation of the interactions between FLPNF and hIAPP. (a) FLPNF was docked into the binding site of hIAPP (total view). (b) Detailed view of the binding mode between FLPNF and hIAPP. hIAPP was represented with cartoon, and the representative binding residues were shown in lines; FLPNF was represented with rose red sticks. The hydrogen bonds were shown as yellow dotted lines.

(a)

(b)