International Journal of Endocrinology / 2019 / Article / Tab 1

Research Article

GNPDA2 Gene Affects Adipogenesis and Alters the Transcriptome Profile of Human Adipose-Derived Mesenchymal Stem Cells

Table 1

GO biological processes enrichment analysis results (OEG vs. V1).

IDDescriptionCount valueDifferentially expressed genes

GO: 0030100Regulation of endocytosis96.42E−06SFRP4/GREM1/PRKD1/SERPINE1/ITGA2/PTX3/SGIP1/DKK1/GAS6
GO: 0045807Positive regulation of endocytosis78.22E−06SFRP4/GREM1/SERPINE1/ITGA2/PTX3/SGIP1/GAS6
GO: 0070371ERK1 and ERK2 cascade101.11E−05CHI3L1/PTPN22/NEK10/IL6/PDGFD/IGF1/CTGF/HTR2B/MIR222/GAS6
GO: 0051781Positive regulation of cell division61.23E−05TGFB2/FGF7/PDGFD/HTR2B/FGF5/EREG
GO: 0050900Leukocyte migration122.99E−05IL6/IGLV3-25/TGFB2/IGHV1-69/GREM1/PDGFD/SERPINE1/ITGA2/B4GALT1/RPS19/SCG2/GAS6
GO: 0051897Positive regulation of protein kinase B signaling74.03E−05CHI3L1/IL6/FGF7/FGF5/MIR222/EREG/GAS6
GO: 0071900Regulation of protein serine/threonine kinase activity112.17E−04CHI3L1/PTPN22/NEK10/RGS4/CEMIP/HSPB1/PDGFD/IGF1/HTR2B/FAM20A/DKK1
GO: 0030595Leukocyte chemotaxis72.45E−04IL6/TGFB2/GREM1/SERPINE1/RPS19/SCG2/GAS6
GO: 0050727Regulation of inflammatory response95.79E−04IL6/IGLV3-25/SOCS5/IGHV1-69/SERPINE1/ITGA2/RPS19/MIR222/NR1D2
GO: 0032675Regulation of interleukin-6 production55.89E−04PTPN22/IL6/SOCS5/EREG/GAS6
GO: 0002685Regulation of leukocyte migration66.29E−04IL6/GREM1/PDGFD/SERPINE1/ITGA2/GAS6
GO: 0032635Interleukin-6 production58.39E−04PTPN22/IL6/SOCS5/EREG/GAS6
GO: 0006809Nitric oxide biosynthetic process48.80E−04CYP1B1/IL6/DDAH1/PTX3
GO: 0002687Positive regulation of leukocyte migration59.38E−04IL6/PDGFD/SERPINE1/ITGA2/GAS6
GO: 1900165Negative regulation of interleukin-6 secretion21.01E−03PTPN22/GAS6
GO: 0014065Phosphatidylinositol 3-kinase signaling51.04E−03IER3/TGFB2/PDGFD/IGF1/HTR2B
GO: 0046209Nitric oxide metabolic process41.08E−03CYP1B1/IL6/DDAH1/PTX3
GO: 0061097Regulation of protein tyrosine kinase activity41.08E−03SOCS5/GREM1/EREG/GAS6
GO: 2001057Reactive nitrogen species metabolic process41.26E−03CYP1B1/IL6/DDAH1/PTX3
GO: 0010692Regulation of alkaline phosphatase activity21.29E−03TGFB2/ITGA2
GO: 0070886Positive regulation of calcineurin-NFAT signaling cascade21.29E−03LMCD1/IGF1
GO: 0071902Positive regulation of protein serine/threonine kinase activity81.36E−03CHI3L1/NEK10/CEMIP/PDGFD/IGF1/HTR2B/FAM20A/DKK1
GO: 0002090Regulation of receptor internalization31.59E−03SFRP4/GREM1/DKK1
GO: 0032715Negative regulation of interleukin-6 production31.59E−03PTPN22/SOCS5/GAS6
GO: 0060394Negative regulation of pathway-restricted SMAD protein phosphorylation21.61E−03GREM1/DKK1
GO: 0031952Regulation of protein autophosphorylation31.99E−03NEK10/GREM1/PDGFD
GO: 0045429Positive regulation of nitric oxide biosynthetic process32.13E−03IL6/DDAH1/PTX3

The differentially expressed genes with are listed in the table, which are categorized by GO analysis of biological processes. For example, 9 of the filtered genes belonged to the category “regulation of endocytosis.” The 9 genes are proportionally more than in the reference gene set as specified by value (6.42E−06).

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