International Journal of Endocrinology / 2019 / Article / Tab 2

Research Article

GNPDA2 Gene Affects Adipogenesis and Alters the Transcriptome Profile of Human Adipose-Derived Mesenchymal Stem Cells

Table 2

GO biological processes enrichment analysis results (InG vs. V2).

IDDescriptionCount valueDifferentially expressed genes

GO: 0006631Fatty acid metabolic process595.73E−25PDK4/ETFA/GHR/HACD2/ABHD5/ABCD2/LEP/LIPE/ECHDC1/ACSL4/ETFDH/CNR1/ACSF2/DECR1/ACAA2/ACACB/HADH/HACD1/ACADM/PPARG/LPL/DLAT/PHYH/IRS2/ACAT2/PRKAR2B/ACSL3/AACS/ALDH3A2/PNPLA3/ADIPOQ/MLXIPL/NDUFAB1/ACOX1/HSD17B4/ACSS2/HACL1/MLYCD/FADS2/ACADSB/PDPN/FABP3/PDHB/PDHX/ACSL1/CPT2/LPIN1/PCCA/ACOT1/SREBF1/DGAT2/ECHS1/ACADL/GPAM/MSMO1/ADIPOR2/DLD/PDHA1/OLAH

GO: 0019395Fatty acid oxidation294.74E−20PDK4/ETFA/ABCD2/LEP/ECHDC1/ETFDH/CNR1/DECR1/ACAA2/ACACB/HADH/ACADM/PPARG/PHYH/IRS2/ACAT2/ALDH3A2/ADIPOQ/NDUFAB1/ACOX1/HSD17B4/HACL1/MLYCD/FABP3/CPT2/DGAT2/ECHS1/ACADL/ADIPOR2

GO: 0034440Lipid oxidation298.88E−20PDK4/ETFA/ABCD2/LEP/ECHDC1/ETFDH/CNR1/DECR1/ACAA2/ACACB/HADH/ACADM/PPARG/PHYH/IRS2/ACAT2/ALDH3A2/ADIPOQ/NDUFAB1/ACOX1/HSD17B4/HACL1/MLYCD/FABP3/CPT2/DGAT2/ECHS1/ACADL/ADIPOR2

GO: 0019216Regulation of lipid metabolic process451.67E−14PDK4/ABHD5/ABCD2/PDE3B/LEP/CNR1/HCAR2/SORBS1/ACACB/ACADM/PPARG/DLAT/ANGPTL4/IRS2/IDH1/PPP2R5A/LYN/NCOA1/NSMAF/ACSL3/LSS/ADIPOQ/MLXIPL/THRSP/ACOX1/IDI1/LGALS12/FDPS/ME1/MLYCD/FABP3/PDHB/PDHX/ACSL1/CPT2/PNPLA2/SREBF1/DGAT2/NR1D1/ACADL/GPAM/ADIPOR2/FDFT1/DLD/PDHA1

GO: 0019217Regulation of fatty acid metabolic process193.28E−11PDK4/ABCD2/CNR1/ACACB/PPARG/DLAT/IRS2/ADIPOQ/MLXIPL/MLYCD/FABP3/PDHB/PDHX/SREBF1/DGAT2/ACADL/ADIPOR2/DLD/PDHA1

GO: 0030258Lipid modification312.90E−09PDK4/ETFA/ABCD2/LEP/KLB/ECHDC1/ETFDH/CNR1/DECR1/ACAA2/ACACB/HADH/ACADM/PPARG/PTEN/PHYH/IRS2/ACAT2/ALDH3A2/ADIPOQ/NDUFAB1/ACOX1/HSD17B4/HACL1/MLYCD/FABP3/CPT2/DGAT2/ECHS1/ACADL/ADIPOR2

GO: 0032868Response to insulin294.08E−09PDK4/UCP2/PCK1/PDE3B/LEP/SOS1/SLC25A33/PFKFB1/ACVR1C/SORBS1/HADH/ATP6V1D/PPARG/PTEN/IRS2/LYN/KANK1/CAT/ADIPOQ/CPEB1/CRY1/KAT2B/FABP3/LPIN1/SREBF1/SORT1/DENND4C/SIK2/OPA1

GO: 0046320Regulation of fatty acid oxidation101.15E−08PDK4/ABCD2/CNR1/ACACB/PPARG/IRS2/MLYCD/FABP3/DGAT2/ACADL

GO: 0019915Lipid storage129.09E−07HILPDA/ABHD5/LEP/ACVR1C/ACACB/PPARG/LPL/LDAH/OSBPL11/CRY1/PNPLA2/DGAT2

GO: 0032869Cellular response to insulin stimulus212.21E−06PDK4/UCP2/PCK1/PDE3B/LEP/SOS1/SLC25A33/SORBS1/ATP6V1D/PPARG/PTEN/IRS2/KANK1/ADIPOQ/CPEB1/KAT2B/LPIN1/SREBF1/DENND4C/SIK2/OPA1

GO: 0045834Positive regulation of lipid metabolic process163.13E−06ABHD5/ABCD2/SORBS1/PPARG/IRS2/LYN/NSMAF/ACSL3/ADIPOQ/MLXIPL/MLYCD/FABP3/PNPLA2/SREBF1/DGAT2/NR1D1

GO: 0010889Regulation of sequestering of triglyceride52.59E−05ABHD5/PPARG/LPL/OSBPL11/PNPLA2

GO: 0010876Lipid localization292.94E−05HILPDA/ABHD5/ABCD2/LEP/ACSL4/ACVR1C/ACACB/PPARG/LPL/LDAH/OSBPL11/IRS2/FZD4/CHKA/NCOA1/ACSL3/ADIPOQ/RBP4/THRSP/CRY1/FABP3/ACSL1/CPT2/ATP11C/PNPLA2/DGAT2/BDKRB2/ABCA10/PITPNA

GO: 0015909Long-chain fatty acid transport103.94E−05ABCD2/ACACB/PPARG/IRS2/ACSL3/THRSP/FABP3/ACSL1/CPT2/BDKRB2

GO: 0015908Fatty acid transport124.62E−05ABCD2/LEP/ACSL4/ACACB/PPARG/IRS2/ACSL3/THRSP/FABP3/ACSL1/CPT2/BDKRB2

GO: 0010883Regulation of lipid storage86.12E−05HILPDA/ABHD5/LEP/ACACB/PPARG/LPL/OSBPL11/PNPLA2

GO: 0045444Fat cell differentiation197.69E−05ADIRF/FBXO9/ITGA6/LEP/PPARG/FABP4/OSBPL11/MIR29B1/SULT1E1/AACS/ADIPOQ/LGALS12/ARNTL/TMEM120A/SREBF1/NR1D1/LMO3/SORT1/SFRP2

GO: 0030730Sequestering of triglyceride59.02E−05ABHD5/PPARG/LPL/OSBPL11/PNPLA2

GO: 0010891Negative regulation of sequestering of triglyceride33.46E−04ABHD5/PPARG/PNPLA2

GO: 0033500Carbohydrate homeostasis183.88E−04PDK4/OXCT1/UCP2/PCK1/LEP/CNR1/PPARG/EFNA5/IRS2/AACS/ADIPOQ/MLXIPL/RBP4/CRY1/PYGL/NR1D1/ADIPOR2/OPA1

GO: 0042593Glucose homeostasis183.88E−04PDK4/OXCT1/UCP2/PCK1/LEP/CNR1/PPARG/EFNA5/IRS2/AACS/ADIPOQ/MLXIPL/RBP4/CRY1/PYGL/NR1D1/ADIPOR2/OPA1

GO: 0070542Response to fatty acid104.14E−04PDK4/UCP2/PPARG/CAT/AACS/ADIPOQ/FABP3/ACSL1/SREBF1/DGAT2

GO: 0055088Lipid homeostasis124.75E−04PPARG/LPL/FABP4/ANGPTL4/IRS2/PNPLA3/MLXIPL/FABP3/PNPLA2/DGAT2/NR1D1/GPAM

GO: 0045923Positive regulation of fatty acid metabolic process65.66E−04ABCD2/PPARG/IRS2/ADIPOQ/MLXIPL/MLYCD

GO: 0045598Regulation of fat cell differentiation125.99E−04ADIRF/LEP/PPARG/MIR29B1/SULT1E1/ADIPOQ/LGALS12/ARNTL/NR1D1/LMO3/SORT1/SFRP2

GO: 0046321Positive regulation of fatty acid oxidation49.22E−04ABCD2/PPARG/IRS2/MLYCD

GO: 0010888Negative regulation of lipid storage42.03E−03ABHD5/LEP/PPARG/PNPLA2

The differentially expressed genes with are listed in the table, which are categorized by GO analysis of biological processes. For example, 59 of the filtered genes belonged to the category “fatty acid metabolic process.” The 59 genes are proportionally more than in the reference gene set as specified by value (5.73E−25).

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