International Journal of Endocrinology

Research Article

GNPDA2 Gene Affects Adipogenesis and Alters the Transcriptome Profile of Human Adipose-Derived Mesenchymal Stem Cells

Table 2

GO biological processes enrichment analysis results (InG vs. V2).
IDDescriptionCount valueDifferentially expressed genes
GO: 0006631Fatty acid metabolic process595.73E−25PDK4/ETFA/GHR/HACD2/ABHD5/ABCD2/LEP/LIPE/ECHDC1/ACSL4/ETFDH/CNR1/ACSF2/DECR1/ACAA2/ACACB/HADH/HACD1/ACADM/PPARG/LPL/DLAT/PHYH/IRS2/ACAT2/PRKAR2B/ACSL3/AACS/ALDH3A2/PNPLA3/ADIPOQ/MLXIPL/NDUFAB1/ACOX1/HSD17B4/ACSS2/HACL1/MLYCD/FADS2/ACADSB/PDPN/FABP3/PDHB/PDHX/ACSL1/CPT2/LPIN1/PCCA/ACOT1/SREBF1/DGAT2/ECHS1/ACADL/GPAM/MSMO1/ADIPOR2/DLD/PDHA1/OLAH
GO: 0019395Fatty acid oxidation294.74E−20PDK4/ETFA/ABCD2/LEP/ECHDC1/ETFDH/CNR1/DECR1/ACAA2/ACACB/HADH/ACADM/PPARG/PHYH/IRS2/ACAT2/ALDH3A2/ADIPOQ/NDUFAB1/ACOX1/HSD17B4/HACL1/MLYCD/FABP3/CPT2/DGAT2/ECHS1/ACADL/ADIPOR2
GO: 0034440Lipid oxidation298.88E−20PDK4/ETFA/ABCD2/LEP/ECHDC1/ETFDH/CNR1/DECR1/ACAA2/ACACB/HADH/ACADM/PPARG/PHYH/IRS2/ACAT2/ALDH3A2/ADIPOQ/NDUFAB1/ACOX1/HSD17B4/HACL1/MLYCD/FABP3/CPT2/DGAT2/ECHS1/ACADL/ADIPOR2
GO: 0019216Regulation of lipid metabolic process451.67E−14PDK4/ABHD5/ABCD2/PDE3B/LEP/CNR1/HCAR2/SORBS1/ACACB/ACADM/PPARG/DLAT/ANGPTL4/IRS2/IDH1/PPP2R5A/LYN/NCOA1/NSMAF/ACSL3/LSS/ADIPOQ/MLXIPL/THRSP/ACOX1/IDI1/LGALS12/FDPS/ME1/MLYCD/FABP3/PDHB/PDHX/ACSL1/CPT2/PNPLA2/SREBF1/DGAT2/NR1D1/ACADL/GPAM/ADIPOR2/FDFT1/DLD/PDHA1
GO: 0019217Regulation of fatty acid metabolic process193.28E−11PDK4/ABCD2/CNR1/ACACB/PPARG/DLAT/IRS2/ADIPOQ/MLXIPL/MLYCD/FABP3/PDHB/PDHX/SREBF1/DGAT2/ACADL/ADIPOR2/DLD/PDHA1
GO: 0030258Lipid modification312.90E−09PDK4/ETFA/ABCD2/LEP/KLB/ECHDC1/ETFDH/CNR1/DECR1/ACAA2/ACACB/HADH/ACADM/PPARG/PTEN/PHYH/IRS2/ACAT2/ALDH3A2/ADIPOQ/NDUFAB1/ACOX1/HSD17B4/HACL1/MLYCD/FABP3/CPT2/DGAT2/ECHS1/ACADL/ADIPOR2
GO: 0032868Response to insulin294.08E−09PDK4/UCP2/PCK1/PDE3B/LEP/SOS1/SLC25A33/PFKFB1/ACVR1C/SORBS1/HADH/ATP6V1D/PPARG/PTEN/IRS2/LYN/KANK1/CAT/ADIPOQ/CPEB1/CRY1/KAT2B/FABP3/LPIN1/SREBF1/SORT1/DENND4C/SIK2/OPA1
GO: 0046320Regulation of fatty acid oxidation101.15E−08PDK4/ABCD2/CNR1/ACACB/PPARG/IRS2/MLYCD/FABP3/DGAT2/ACADL
GO: 0019915Lipid storage129.09E−07HILPDA/ABHD5/LEP/ACVR1C/ACACB/PPARG/LPL/LDAH/OSBPL11/CRY1/PNPLA2/DGAT2
GO: 0032869Cellular response to insulin stimulus212.21E−06PDK4/UCP2/PCK1/PDE3B/LEP/SOS1/SLC25A33/SORBS1/ATP6V1D/PPARG/PTEN/IRS2/KANK1/ADIPOQ/CPEB1/KAT2B/LPIN1/SREBF1/DENND4C/SIK2/OPA1
GO: 0045834Positive regulation of lipid metabolic process163.13E−06ABHD5/ABCD2/SORBS1/PPARG/IRS2/LYN/NSMAF/ACSL3/ADIPOQ/MLXIPL/MLYCD/FABP3/PNPLA2/SREBF1/DGAT2/NR1D1
GO: 0010889Regulation of sequestering of triglyceride52.59E−05ABHD5/PPARG/LPL/OSBPL11/PNPLA2
GO: 0010876Lipid localization292.94E−05HILPDA/ABHD5/ABCD2/LEP/ACSL4/ACVR1C/ACACB/PPARG/LPL/LDAH/OSBPL11/IRS2/FZD4/CHKA/NCOA1/ACSL3/ADIPOQ/RBP4/THRSP/CRY1/FABP3/ACSL1/CPT2/ATP11C/PNPLA2/DGAT2/BDKRB2/ABCA10/PITPNA
GO: 0015909Long-chain fatty acid transport103.94E−05ABCD2/ACACB/PPARG/IRS2/ACSL3/THRSP/FABP3/ACSL1/CPT2/BDKRB2
GO: 0015908Fatty acid transport124.62E−05ABCD2/LEP/ACSL4/ACACB/PPARG/IRS2/ACSL3/THRSP/FABP3/ACSL1/CPT2/BDKRB2
GO: 0010883Regulation of lipid storage86.12E−05HILPDA/ABHD5/LEP/ACACB/PPARG/LPL/OSBPL11/PNPLA2
GO: 0045444Fat cell differentiation197.69E−05ADIRF/FBXO9/ITGA6/LEP/PPARG/FABP4/OSBPL11/MIR29B1/SULT1E1/AACS/ADIPOQ/LGALS12/ARNTL/TMEM120A/SREBF1/NR1D1/LMO3/SORT1/SFRP2
GO: 0030730Sequestering of triglyceride59.02E−05ABHD5/PPARG/LPL/OSBPL11/PNPLA2
GO: 0010891Negative regulation of sequestering of triglyceride33.46E−04ABHD5/PPARG/PNPLA2
GO: 0033500Carbohydrate homeostasis183.88E−04PDK4/OXCT1/UCP2/PCK1/LEP/CNR1/PPARG/EFNA5/IRS2/AACS/ADIPOQ/MLXIPL/RBP4/CRY1/PYGL/NR1D1/ADIPOR2/OPA1
GO: 0042593Glucose homeostasis183.88E−04PDK4/OXCT1/UCP2/PCK1/LEP/CNR1/PPARG/EFNA5/IRS2/AACS/ADIPOQ/MLXIPL/RBP4/CRY1/PYGL/NR1D1/ADIPOR2/OPA1
GO: 0070542Response to fatty acid104.14E−04PDK4/UCP2/PPARG/CAT/AACS/ADIPOQ/FABP3/ACSL1/SREBF1/DGAT2
GO: 0055088Lipid homeostasis124.75E−04PPARG/LPL/FABP4/ANGPTL4/IRS2/PNPLA3/MLXIPL/FABP3/PNPLA2/DGAT2/NR1D1/GPAM
GO: 0045923Positive regulation of fatty acid metabolic process65.66E−04ABCD2/PPARG/IRS2/ADIPOQ/MLXIPL/MLYCD
GO: 0045598Regulation of fat cell differentiation125.99E−04ADIRF/LEP/PPARG/MIR29B1/SULT1E1/ADIPOQ/LGALS12/ARNTL/NR1D1/LMO3/SORT1/SFRP2
GO: 0046321Positive regulation of fatty acid oxidation49.22E−04ABCD2/PPARG/IRS2/MLYCD
GO: 0010888Negative regulation of lipid storage42.03E−03ABHD5/LEP/PPARG/PNPLA2
The differentially expressed genes with are listed in the table, which are categorized by GO analysis of biological processes. For example, 59 of the filtered genes belonged to the category “fatty acid metabolic process.” The 59 genes are proportionally more than in the reference gene set as specified by value (5.73E−25).