Research Article

The Phosphatase PHLPP2 Plays a Key Role in the Regulation of Pancreatic Beta-Cell Survival

Figure 5

PHLPP2/1 knock-down results in a significant improvement of cell survival markers expression profile. (a) Representative western blot images of cell survival markers levels in mock-infected INS-1 HG, INS-1 HG AV-LD, and INS-1 HG AV-HD: bad (upper panel), Bcl-xL (middle-upper panel), cleaved caspase-3 (middle-lower panel), and LC3-II (lower panel). (b) Graph of the mean changes of densitometric values of cell survival markers levels in mock-infected INS-1 HG, INS-1 HG AV-LD, and INS-1 HG AV-HD; n = 3–5; indicates significant () differences for AV-infected INS-1 HG vs mock-infected INS-1 HG, indicates significant () differences for INS-1 HG AV-LD vs INS-1 HG AV-HD.
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