The Genetic Perspective of Familial Glucocorticoid Deficiency: In Silico Analysis of Two Novel Variants

Figure 5

Interactome analysis by STRING (V10.5). Protein-protein interaction network; predicted functional partners are as follows: POMC: proopiomelanocortin, MC2R: melanocortin-2 receptor, CRH: corticotropin-releasing hormone, GNAS: GNAS complex locus, CRHR2: corticotropin-releasing hormone receptor 2, NPS: neuropeptide S, LHCGR: luteinizing hormone/choriogonadotropin receptor, CRHR1: corticotropin-releasing hormone receptor 1, and MRAP: melanocortin-2 receptor accessory protein.