Research Article
Germline Mutation in KIF1Bβ Gene Associated with Loss of Heterozygosity: Usefulness of Next-Generation Sequencing in the Genetic Screening of Patients with Pheochromocytoma
Figure 2
Predicted three-dimensional structures of KIF1Bβ, wild-type (a, c, e) and mutant proteins (b, d, f) observed at different angles. The point mutation P1351L was highlighted in red. In light blue, the two kinase domains 1B (aa 799–846; aa 899–928), in blue, DUF3694 domain (aa 1220–1366), and in green, the FHA domain (aa 512–581). The yellow arrows indicate the reduction of the length and width of the kinase domain (e, f).