Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease

Figure 2

The role of TC-derived exosomes in cancer development. Exosomes derived from thyroid cancer cells promote the development of TC by direct and indirect ways. Direct approaches include enhance cell proliferation and invasiveness and promote lymph node metastasis. Indirect approach includes form metastatic niche, stimulate angiogenesis, and induce epithelial-mesenchymal transition to support tumor progress.