Association of rs944289, rs965513, and rs1443434 in TITF1/TITF2 with Risks of Papillary Thyroid Carcinoma and with Nodular Goiter in Northern Chinese Han Populations

Table 5

Association between rs1443434 polymorphism and PTC/NG.

Genotype/allele	PTC vs. NC			NG vs. NC
	OR (95% CI)		AIC	OR (95% CI)		AIC
Codominant
T/T	1.00	0.010	2339.3	1.00	0.370	1747.5
T/G	1.26 (1.01–1.58)			0.90 (0.68–1.18)
G/G	2.21 (1.15–4.23)			0.53 (0.18–1.51)
Dominant
T/T	1.00	0.011	2340.1	1.00	0.320	1746.5
T/G + G/G	1.33 (1.07–1.65)			0.87 (0.67–1.14)
Recessive
T/T + T/G	1.00	0.022	2341.4	1.00	0.230	1746.1
G/G	2.08 (1.09–3.99)			0.54 (0.19–1.54)
Overdominant
T/T + G/G	1.00	0.070	2343.3	1.00	0.490	1747.0
T/G	1.23 (0.98–1.54)			0.91 (0.69–1.20)
Allele
T	1.00	0.003	—	1.00	0.230	—
G	1.33 (1.10–1.61)			1.16 (0.91–1.49)

Adjusted by age. PTC, papillary thyroid carcinoma; NG, nodular goiter; NC, normal control. Bonferroni correction was performed, and was defined as statistical significance. Significant values after Bonferroni correction in bold.