Relationship between Serum Indirect Bilirubin Level and Insulin Sensitivity: Results from Two Independent Cohorts of Obese Patients with Impaired Glucose Regulation and Type 2 Diabetes Mellitus in China

Table 1

Insulin sensitivity indices derived from HEC and OGTT measurements of glucose and insulin.

Index	Formula/equation
M value (mg/kg·min)	GIR + (Ga-Ga-30) × 0.0625
Matsuda Index	10000/(FPG × FINS × Gmean × Imean)^1/2
HOMA-IS = (1/HOMA-IR)	1/[FPG (mmol/L) × FINS (mIU/L)/22.5]

M value, glucose disposal rate (GDR); GIR (mg/kg·min), the glucose infusion rate was measured every 5 min, and the average glucose infusion rate was measured during the final 30 min of HEC; G_a, plasma glucose concentration (mmol/L) at 120 minutes of HEC; G_a-30, plasma glucose concentration (mmol/L) at 90 minutes of HEC; Matsuda Index, insulin sensitivity index by Matsuda; G_mean, mean of plasma glucose concentration (mmol/L) during the OGTT; I_mean, mean of serum insulin concentration (mIU/L) during the OGTT. Abbreviations: HEC, hyperinsulinemic-euglycemic clamp; OGTT, oral glucose tolerance test; HOMA-IS, homeostasis model assessment of insulin sensitivity; HOMA-IR, homeostasis model assessment of insulin resistance; FPG, fasting plasma glucose; FINS, fasting insulin.