International Journal of Endocrinology

Research Article

Relationship between Serum Indirect Bilirubin Level and Insulin Sensitivity: Results from Two Independent Cohorts of Obese Patients with Impaired Glucose Regulation and Type 2 Diabetes Mellitus in China

Table 2

Clinical and metabolic characteristics of the two subgroups at baseline in cohort 1.


	Control group	IGR/T2DM group	t/Z/χ²	value
	(n = 33)	(n = 38)	t/Z/χ²	value

Age (years)	25.33.±7.16	33.68.±10.22	3.909	<0.001
Female, n (%)	11 (33.33%)	19 (50.00%)	2.011	0.156
BW (kg)	98.60 (86.90–112.00)	98.40 (87.50–112.00)	−0.046	0.963
BMI (kg/m²)	36.29 (32.27–39.00)	34.05 (31.01–41.06)	−0.380	0.704
FPG (mmol/L)	4.81 (4.50–5.32)	6.39 (5.20–7.73)	−4.514	<0.001
FINS (mU/L)	28.12 (21.36–30.10)	31.44 (21.46–36.52)	−0.749	0.454
FC-p (pmol/L)	1375.28 ± 390.79	1410.27 ± 457.99	−0.343	0.732
M value (mg/kg·min)	5.01 ± 1.67	3.73 ± 1.65	−3.251	0.002
TBIL (μmol/L)	8.80 (7.60–11.60)	12.00 (8.90–16.00)	−2.513	0.012
DBIL (μmol/L)	3.10 (2.40–4.20)	4.20 (3.20–5.20)	−2.151	0.031
IBIL (μmol/L)	6.20 (4.90–8.10)	7.80 (6.10–10.94)	−2.139	0.032
TC (mmol/L)	4.82 ± 0.98	5.04 ± 1.12	0.878	0.383
TG (mmol/L)	1.26 (0.86–1.69)	1.72 (1.27–2.41)	−2.081	0.037
HDL-c (mmol/L)	1.14 ± 0.17	1.11 ± 0.25	−0.612	0.543
LDL-c (mmol/L)	3.17 (2.67–3.56)	3.23 (2.52–3.85)	−0.386	0.699
ALT (U/L)	30.80 (19.00–68.70)	59.10 (26.20–78.60)	−1.591	0.112
AST (U/L)	26.60 (18.90–38.00)	38.25 (20.20–47.60)	−1.470	0.142
GGT (U/L)	31.00 (21.40–49.50)	42.60 (34.70–66.30)	−2.519	0.012

Data are shown as mean ± SD for normally distributed variables or as median (25^th and 75th percentiles) or n (%), and is considered statistically significant. Abbreviations: IGR/T2DM, impaired glucose regulation and type 2 diabetes mellitus; BW, body weight; BMI, body mass index; FPG, fasting plasma glucose; FINS, fasting insulin; FC-p, fasting C-peptide; M value, glucose disposal rate (GDR); TBIL, total bilirubin; DBIL, direct bilirubin; IBIL, indirect bilirubin; TC, total cholesterol; TG, triglyceride; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; ALT, alanine transaminase; AST, aspartate aminotransferase; GGT, gamma-glutamyl transferase.