Relationship between Serum Indirect Bilirubin Level and Insulin Sensitivity: Results from Two Independent Cohorts of Obese Patients with Impaired Glucose Regulation and Type 2 Diabetes Mellitus in China

Table 4

Multivariate logistic regression analysis, using a cutoff value for insulin resistance of the IGR/T2DM group, after adjustment for metabolism variables in cohort 1.

	Model 1		Model 2		Model 3
	OR (95% CI)	value	OR (95% CI)	value	OR (95% CI)	value
TBIL (μmol/L)	0.744 (0.590–0.938)	0.012	0.744 (0.590–0.938)	0.012	0.744 (0.590–0.938)	0.012
DBIL (μmol/L)	0.575 (0.326–1.015)	0.056	0.575 (0.326–1.015)	0.056	0.575 (0.326–1.015)	0.056
IBIL (μmol/L)	0.602 (0.413–0.878)	0.008	0.602 (0.413–0.878)	0.008	0.602 (0.413–0.878)	0.008

IGR/T2DM, impaired glucose regulation and type 2 diabetes mellitus; SE, standard error; Exp (B), odds ratio; CI, confidence interval; TBIL, total bilirubin; DBIL, direct bilirubin; IBIL, indirect bilirubin; BMI, body mass index; TC, total cholesterol; TG, triglyceride; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; ALT, alanine transaminase; AST, aspartate aminotransferase; GGT, gamma-glutamyl transferase. Multivariate logistic regression analysis, . Statistically significant values are indicated in bold. Model 1: adjusted for age and sex; Model 2: additionally adjusted for BMI, TC, TG, HDL, and LDL; Model 3: additionally adjusted for ALT, AST, and GGT.