Clinical Study

Parathyroid Hormone Reduction Predicts Transient Hypocalcemia after Total Thyroidectomy: A Single-Center Prospective Study

Table 4

The risk factors for the transient hypocalcemia on postoperative day 1.

VariableUnivariateMultivariate
βOR (95% CI)βOR (95% CI)

The whole cohort (n = 176)
 Gender1.2683.555 (1.302–9.703)0.0131.1603.189 (0.924–11.007)0.067
 Age (year)−0.0170.983 (0.954–1.012)0.251−0.0010.999 (0.961–1.039)0.957
 PTH reduction (%)0.0471.048 (1.028–1.068)<0.0010.0431.044 (1.023–1.065)<0.001
 Preoperative PTH (pg/ml)0.0021.002 (0.958–1.019)0.849−0.0100.990 (0.969–1.011)0.337
 Preoperative serum Ca (mmol/L)−1.6710.188 (0.015–2.295)0.190−3.0230.049 (0.001–1.786)0.100
 Tumor diameter (cm)0.4101.507 (1.059–2.145)0.0230.4471.564 (0.981–2.496)0.060
 Surgery0.9522.590 (0.725–9.261)0.1431.0022.722 (0.518–14.318)0.237

Bilateral group (n = 125)
 Gender1.2353.440 (1.243–9.523)0.0171.1553.176 (0.907–11.113)0.071
 Age (year)−0.0150.985 (0.955–1.015)0.3200.0031.003 (0.964–1.044)0.883
 PTH reduction (%)0.0471.048 (1.028–1.069)<0.0010.0421.043 (1.022–1.064)<0.001
 Preoperative PTH (pg/ml)−0.0050.995 (0.977–1.013)0.562−0.0180.982 (0.960–1.004)0.114
 Preoperative serum Ca (mmol/L)−1.1230.325 (0.029–3.595)0.360−0.30240.049 (0.001–1.920)0.107
 Tumor diameter (cm)0.3891.476 (1.032–2.111)0.0330.4651.592 (0.992–2.554)0.054

Female patients (n = 137)
 Age (year)−0.0160.984 (0.953–1.016)0.316−0.0010.999 (0.958–1.042)0.964
 PTH reduction (%)0.0511.053 (1.030–1.076)<0.0010.0491.050 (1.026–1.075)<0.001
 Preoperative PTH (pg/ml)0.0041.004 (0.987–1.022)0.643−0.0060.994 (0.972–1.016)0.582
 Preoperative serum Ca (mmol/L)−1.7840.168 (0.012–2.278)0.180−3.5690.028 (0.001–1.366)0.071
 Tumor diameter (cm)0.4461.563 (1.070–2.283)0.0210.4991.647 (1.003–2.704)0.049

Male patients (n = 39)
 Age (year)−0.0240.976 (0.900–1.059)0.558−0.0120.988 (0.869–1.123)0.853
 PTH reduction (%)0.0271.028 (0.988–1.069)0.1710.0231.023 (0.981–1.068)0.285
 Preoperative PTH (pg/ml)−0.0280.973 (0.909–1.041)0.424−0.0510.951 (0.867–1.043)0.284
 Preoperative serum Ca (mmol/L)0.1041.019 (0.000–31.581)0.984−0.2800.756 (0.000–12.050)0.964
 Tumor diameter (cm)0.1201.127 (0.364–3.489)0.8360.1941.215 (0.242–6.100)0.813