Vitamin D Auto-/Paracrine System Is Involved in Modulation of Glucocorticoid-Induced Changes in Angiogenesis/Bone Remodeling Coupling

Table 1

Bone turnover characteristics of rats with glucocorticoids-induced osteoporosis and after vitamin D₃ administration, M ± m (n = 10).

Tissue	Characteristic/variable	Control	Prednisolone administration	Prednisolone and vitamin D3 administration
Serum	Total calcium, mM·L^−1	2.23 ± 0.2	1.91 ± 0.05	2.20 ± 0.03^#
	Protein-bound calcium, mM·L^−1	0.24 ± 0.03	0.22 ± 0.04	0.21 ± 0.04
	Ultrafiltered calcium, mM·L^−1	1.99 ± 0.04	1.69 ± 0.03	1.99 ± 0.05^#
	Inorganic phosphate, mM·L^−1	2.22 ± 0.06	1.86 ± 0.07	2.26 ± 0.04^#
	Total activity of alkaline phosphatase, IU/L	233.1 ± 6.3	352.7 ± 9.2	250.5 ± 5.1^#
	Activity of intestinal isoenzyme, IU/L	44.5 ± 1.68	64.7 ± 1.86	48.3 ± 1.52^#
	Activity of bone isoenzyme, IU/L	158.2 ± 5.4	264.3 ± 7.2	181.6 ± 5.9^#
Rat tibia	Ash content, %	56.0 ± 2.4	47.0 ± 1.9	52.0 ± 2.0^#
	Calcium content, %	30.2 ± 0.29	26.1 ± 0.7	31.6 ± 0.6^#
	Inorganic phosphate content, %	19.2 ± 0.18	16.3 ± 0.6	18.2 ± 0.5^#

Values are given as means ± SEM (n = 10); vs. control; vs. prednisolone administration