Vitamins Modulate the Expression of Antioxidant Genes in Progesterone-Treated Pancreatic β Cells: Perspectives for Gestational Diabetes Management

Figure 4

Expression of Scd1 gene in progesterone-treated RINm5F cells, in the presence of antioxidants. Cells were preincubated with 40 μM vitamin E (a) or 50 μM vitamin C (b) for 2 h, and then with 0.1, 1.0, or 100 μM progesterone 6 or 24 h. Data are presented as means ± SEM of three experiments in duplicates. indicates difference compared to control. indicates difference between the incubation time points, for the same progesterone concentration. $ indicates difference in comparison to the treatment without antioxidants (ρ < 0.05). PG: progesterone; Vit E: vitamin E; Vit C: vitamin C.

(a)

(b)