Serum Levels of Asprosin, a Novel Adipokine, Are Significantly Lowered in Patients with Acromegaly
Table 1
Basic characteristics of acromegaly patients and controls.
Variables
Acromegaly (N = 68)
Controls (N = 121)
P
M/F, %
29/39, 74% (68)
43/78, 55% (121)
0.334
Age (y)!
41.3 ± 15.0 (68)
44.5 ± 13.0 (121)
0.146
SBP (mmHg)
123.2 ± 14.5 (68)
125.1 ± 18.7 (121)
0.565
DBP (mmHg)
77.5 ± 11.9 (67)
79.1 ± 11.8 (121)
0.349
BMI (kg/cm2)
25.79 ± 3.52 (66)
26.44 ± 3.41 (121)
0.192
ALT (U/L)!
18.4 ± 9.7 (67)
22.4 ± 1.2 (120)
0.027
AST (U/L)!
18.2 ± 6.2 (44)
21.0 ± 7.6 (115)
0.030
Cr (μmol/l)!
55.0 ± 12.3 (66)
78.1 ± 23.3 (120)
<0.001
UA (μmol/l)
277 ± 77 (61)
274 ± 75 (114)
0.762
TC (mmol/l)
4.49 ± 0.85 (36)
4.81 ± 0.85 (119)
0.033
TG (mmol/l)!
1.79 ± 1.09 (36)
1.72 ± 1.37 (119)
0.328
HDL-C (mmol/l)!
1.19 ± 0.31 (36)
1.40 ± 0.36 (115)
0.004
LDL-C (mmol/l)
2.62 ± 0.74 (36)
2.93 ± 0.70 (113)
0.013
FBG (mmol/l)!
6.0 ± 1.7 (66)
5.4 ± 0.9 (119)
0.003
2h-Glu (mmol/l)
9.0 ± 3.9 (66)
8.0 ± 3.3 (66)
0.081
Glu-AUC (mmol/l)
1615.3 ± 552.1 (66)
NA
NA
Asprosin (ng/ml)!
2.18 ± 0.86 (68)
2.71 ± 0.86 (114)
<0.001
D-max (mm)
19.8 ± 9.0 (59)
—
—
Course (y)
5.0 (2.3, 10.0) (68)
—
—
IGF-1 SDS
6.56 ± 2.43 (66)
—
—
GH (ng/ml)
15.0 (7.2, 32.6) (66)
—
—
GH-nadir (ng/ml)
10.7 (5.1, 24.0) (65)
—
—
GH-AUC (ng/ml)
2391.0 (1345.0, 5673.0) (65)
—
—
Values are expressed as mean ± standard deviation or median (P25, P75). !, non-parametric test. SBP: systolic blood pressure; DBP: diastolic blood pressure; FBG: fasting blood glucose; 2 h-Glu: 2-hour postprandial blood glucose; GLU-AUC: glucose of the area under curve of 75 g OGTT; D-max: maximum of tumor diameter; Course: course of acromegaly; IGF-1 SDS : SDS of insulin-like growth factor; GH-Nadir: nadir GH level after 75 g OGTT; GH-AUC: growth hormone of the area under curve of 75 g OGTT; NA, not available. Bold values indicate statistical significance .
