Postoperative Nomogram for Predicting Cancer-Specific and Overall Survival among Patients with Medullary Thyroid Cancer

Table 3

Univariate and multivariate cox regression analysis of cancer-specific survival (CSS) in the training cohort.

Characteristics	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Age (y)
<48	Reference
48–71	4.017	1.685–9.557	0.002	4.967	2.058–11.992	≤0.001
>71	10.827	4.223–27.761	≤0.001	13.397	5.004–35.863	≤0.001
Race
Black	Reference
White	0.843	0.336–2.115	0.715	—	—	—
Others	0.231	0.027–1.975	0.181	—	—	—
Sex
Male	Reference
Female	0.573	0.337–0.973	0.039	—	—	—
Number of nodules
Solitary	Reference
Multiple	0.843	0.472–1.507	0.565	—	—	—
Tumor size (mm)
<20	Reference
20–40	5.022	2.053–12.287	≤0.001	4.476	1.813–11.048	≤0.001
>40	11.455	4.712–27.846	≤0.001	5.558	2.223–13.895	≤0.001
T
T1a	Reference
T1b	1.060	0.149–7.529	0.953	—	—	—
T2	4.081	0.881–18.904	0.072	—	—	—
T3a	5.536	1.150–26.655	0.033	—	—	—
T3b	13.180	3.014–57.640	≤0.001	—	—	—
T4a	29.048	6.518–129.457	≤0.001	—	—	—
T4b	27.548	5.691–133.349	≤0.001	—	—	—
N
N0	Reference
N1a	5.847	2.388–14.313	≤0.001	—	—	—
N1b	7.443	3.236–17.122	≤0.001	—	—	—
M
M0	Reference
M1	12.854	7.382–22.384	≤0.001	6.694	3.690–12.145	≤0.001
Number of removal LNs
1–3	Reference
≥4	1.015	0.520–1.981	0.965	—	—	—
Total LNs
0–11	Reference
12–32	1.295	0.665–2.518	0.447	—	—	—
33–90	1.79	0.958–3.343	0.068	—	—	—
pLNs
0	Reference
1–16	5.737	2.506–13.131	≤0.001	—	—	—
17–63	11.917	4.823–29.444	≤0.001	—	—	—
LNR
<19.00%	Reference
19.00%–49.00%	4.536	2.117–9.720	≤0.001	3.287	1.493–7.235	0.003
>49.00%	9.875	4.868–20.034	≤0.001	5.874	2.794–12.352	≤0.001