Research Article

Classification of Thyroid Nodules with Stacked Denoising Sparse Autoencoder

Table 3

Performance of the IRC based on SDSAE.

ParameterTraining set (n = 929)Independent testing set (n = 84)
ValueCI of 95%ValueCI of 95%

Proportion of malignancy85.8%85.7%
Area under the curve0.8870.855–0.9200.7850.638–0.931
Accuracy92.0%92.0–92.0%92.9%92.7–93.0%
Sensitivity93.4%91.6–95.1%98.6%95.9–101.3%
Specificity84.1%77.9–90.3%58.3%30.4–86.2%
Positive likelihood ratio5.8683.962–8.6892.3671.211–4.625
Negative likelihood ratio0.0790.060–0.1040.0240.003–0.177
Positive predictive value97.3%96.1–98.4%93.4%87.8–99%
Negative predictive value67.7%60.5–74.8%87.5%64.6–110.4%

IRC: immune-related classifier; SDSAE: stacked denoising sparse autoencoder; CI: confidence interval.