Is There a Nonlinear Relationship between Serum Uric Acid and Lipids in a Hypertensive Population with eGFR ≥30 ml/min/1.73 m²? Findings from the China Hypertension Registry Study

Table 1

Characteristics of study population.

Characteristics	Total	Tertiles of SUA (mg/dL)			value
		T1 (<5.57)	T2 (5.57–8.39)	T3 (≥8.39)
N	13,355	4,464	4,514	4,377
Demographics
Age (years)	63.77 ± 9.33	63.27 ± 8.79	64.10 ± 9.29	63.96 ± 9.86	<0.001
Male (%)	6301 (47.18)	1145 (25.65)	2226 (49.31)	2930 (66.94)	<0.001
Smoking (%)	3443 (25.79)	783 (17.54)	1235 (27.37)	1425 (32.56)	<0.001
Alcohol use (%)	2906 (21.77)	559 (12.53)	1025 (22.71)	1322 (30.21)	<0.001
Comorbidity (%)
Stroke	923 (6.91)	303 (6.79)	307 (6.80)	313 (7.15)	0.747
CHD	689 (5.16)	193 (4.32)	232 (5.14)	264 (6.03)	0.004
Diabetes	2451 (18.35)	742 (16.62)	821 (18.19)	888 (20.29)	<0.001
Medication use (%)
Antihypertensive drugs	8617 (64.54)	2757 (61.77)	2907 (64.41)	2953 (67.48)	<0.001
Lipid-lowering drugs	478 (3.58)	170 (3.81)	146 (3.23)	162 (3.70)	0.298
Glucose-lowering drugs	694 (5.20)	251 (5.62)	216 (4.79)	227 (5.19)	0.202
Physical examination
BMI (kg/m^2)	23.64 ± 3.75	23.18 ± 3.53	23.61 ± 4.07	24.12 ± 3.55	<0.001
SBP (mmHg)	148.41 ± 18.30	149.88 ± 17.52	148.52 ± 19.05	146.81 ± 18.15	<0.001
DBP (mmHg)	89.00 ± 11.61	88.53 ± 10.42	89.06 ± 13.14	89.41 ± 11.07	0.002
Biomarkers
TC (mmol/L)	5.16 ± 1.11	5.09 ± 1.07	5.16 ± 1.10	5.22 ± 1.16	<0.001
TG (mmol/L)	1.80 ± 1.25	1.60 ± 1.00	1.78 ± 1.26	2.02 ± 1.43	<0.001
LDL-C (mmol/L)	2.98 ± 0.81	2.93 ± 0.79	2.99 ± 0.81	3.03 ± 0.84	<0.001
HDL-C (mmol/L)	1.57 ± 0.42	1.61 ± 0.43	1.56 ± 0.42	1.53 ± 0.42	<0.001
Hcy (μmol/L)	17.70 ± 10.74	15.47 ± 8.30	17.66 ± 10.33	20.02 ± 12.69	<0.001
FBG (mmol/L)	6.18 ± 1.59	6.15 ± 1.73	6.15 ± 1.54	6.23 ± 1.48	0.023
AST (U/L)	26.74 ± 15.39	24.68 ± 9.57	26.79 ± 20.29	28.79 ± 14.03	<0.001
ALT (U/L)	20.47 ± 16.49	17.80 ± 10.86	20.57 ± 20.17	23.10 ± 16.62	<0.001
eGFR (ml/min/1.73 m^2)	89.33 ± 18.16	97.11 ± 14.21	89.82 ± 16.58	80.91 ± 19.59	<0.001

Abbreviations: SUA, serum uric acid; CHD, coronary heart disease; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; Hcy, homocysteine; FBG, fasting blood glucose; AST, aspartate aminotransferases; ALT, alanine transaminase; eGFR, estimated glomerular filtration rate. Data are presented as number (%) or mean ± standard deviation.