MEK1/2 Inhibitor (GDC0623) Promotes Osteogenic Differentiation of Primary Osteoblasts Inhibited by IL-1β through the MEK-Erk1/2 and Jak/Stat3 Pathways

Figure 2

Comparisons of ALP staining and activities among the control, IL-1β, and GDC0623 groups. (a) Osteoblasts were stained for ALP levels after being induced with an osteogenic differentiation medium for 7 days (upper lane). Details of ALP staining at day 7 (lower lane). (b) ALP activities were detected after cell induction for 7 days. Data are expressed as mean ± SD for n = 3.  < 0.05 versus the control group;  < 0.05 versus the IL-1β group.

(a)

(b)