International Journal of Endocrinology

Research Article

The rs1634330 Polymorphisms in the SOST Gene Are Associated with Body Composition in Chinese Nuclear Families with Male Offspring

Table 5

P values of tests for population stratification, total association, and within-family association in SOST tag SNPs using QTDT.


	rs7220711	rs1513670	rs865429	rs851057	rs2023794	rs851058	rs74252774	rs1708635	rs1634330	rs1234612

Tests of population stratification
BMI	0.7074	0.6894	0.7586	0.7587	0.8942	0.4900	0.7200	0.4716	0.4893	0.8076
Arms FM	0.0048	0.0165	0.2552	0.0732	0.6766	0.6049	0.9380	0.7242	0.7303	0.6490
Trunk FM	0.0254	0.0070	0.1334	0.0341	0.6383	0.4957	1.000	0.6549	0.6644	0.4218
Legs FM	0.0092	0.0580	0.0507	0.1997	0.4166	0.7020	0.6692	0.7908	0.8235	0.1418
Total FM	0.1185	0.1368	1.0000	0.0554	0.2569	1.0000	0.0303	1.0000	0.8551	0.6295
PFM	0.1153	0.3676	0.9686	0.7228	0.6640	0.8898	0.7927	0.9960	0.9757	0.4735
Arms LM	0.1239	0.4489	0.6243	0.7506	0.9115	0.3548	0.9985	0.4969	0.5412	0.9973
Trunk LM	0.5131	1.0000	0.2753	1.0000	0.4952	1.0000	1.0000	1.0000	0.7838	1.0000
Legs LM	0.1240	0.4516	0.8182	0.9848	0.7818	0.8764	1.0000	0.7451	0.7795	0.8853
Total LM	0.0172	0.1939	0.5489	0.7441	0.3545	0.2245	1.0000	0.2848	0.4609	1.0000
PLM	0.3937	0.9953	0.7482	0.6091	0.6667	0.8943	0.8248	0.9387	0.9776	0.4766

Tests of total association
BMI	0.1142	0.2459	0.3638	0.2068	0.4186	0.4013	0.4467	0.4696	0.4545	0.5933
Arms FM	0.4535	0.0842	0.8849	0.0968	0.7375	0.6908	0.9506	0.5982	0.5941	0.6581
Trunk FM	0.4794	0.0305	0.5984	0.0399	0.6767	0.4312	0.8598	0.3854	0.3807	0.9208
Legs FM	0.8614	0.1845	0.7668	0.2279	0.8633	0.9596	0.9311	0.8576	0.8532	0.7517
Total FM	0.3567	0.0697	0.6320	0.1024	1.0000	0.7282	1.0000	0.6995	0.6738	0.8949
PFM	0.9585	0.2622	0.4958	0.6412	0.9750	0.7642	0.7684	0.9840	0.9939	0.1933
Arms LM	0.9474	0.3626	0.7602	0.6595	0.7027	0.8896	0.8348	0.7267	0.7276	0.6528
Trunk LM	0.5472	0.5204	1.0000	1.0000	1.0000	0.9470	0.7455	0.6553	0.6528	0.2226
Legs LM	0.9256	0.3803	0.6209	0.7734	0.8946	1.0000	0.9760	0.7943	0.7841	0.2845
Total LM	0.5000	0.1247	0.5408	0.5108	0.9062	0.9663	0.9218	0.5606	0.5544	0.0216
PLM	0.5649	0.6311	0.5855	0.8600	1.0000	0.7001	0.7971	0.9627	0.9678	0.1491

Tests of within-family association
BMI	0.2775	0.3756	0.9067	0.3953	0.7896	0.8153	0.5033	0.7473	0.7760	0.6544
Arms FM	0.0042	0.0038	0.3213	0.0205	0.8167	0.5253	0.9231	0.5924	0.5958	0.8017
Trunk FM	0.0207	0.0008	0.1091	0.0054	0.7916	0.3342	1.0000	0.4481	0.4470	0.4615
Legs FM	0.0157	0.0229	0.0556	0.0954	0.5109	0.7119	0.6709	0.7524	0.7790	0.2183
Total FM	0.0080	0.0070	0.2781	0.0141	0.6715	0.6309	1.0000	0.6646	1.0000	1.0000
PFM	0.2011	0.1732	0.7028	0.5826	0.7312	0.9657	0.7029	1.0000	0.9755	0.2026
Arms LM	0.2015	0.2661	0.7754	0.6197	0.9173	0.3837	0.9144	0.4451	0.4820	0.6600
Trunk LM	0.7724	0.4325	0.6181	0.6255	0.4947	0.6238	0.7352	0.4396	0.0049	0.3835
Legs LM	0.2007	1.0000	0.9831	0.8793	0.8470	0.6209	0.9872	0.6821	0.6998	0.5455
Total LM	0.0860	0.0588	0.6200	0.5459	0.4581	0.2041	0.9568	0.2234	0.2579	0.1249
PLM	0.6961	0.8008	1.0000	0.5987	0.7195	0.9266	0.7445	0.9672	1.0000	0.1814

P 1000 permutation of within-family association
BMI	0.2930	0.3870	0.9170	0.4040	0.7880	0.8320	0.5220	0.7390	0.7690	0.6740
Arms FM	0.0740	0.0410	0.5470	0.1040	0.8630	0.6970	0.9530	0.7170	0.7170	0.8840
Trunk FM	0.1560	0.0230	0.2910	0.0680	0.8010	0.5500	0.9330	0.6450	0.6430	0.6430
Legs FM	0.0930	0.0890	0.1750	0.2150	0.6300	0.8000	0.7640	0.8260	0.8430	0.3940
Total FM	0.1270	0.0860	0.4170	0.1090	0.6320	0.6410	0.7510	0.6360	0.8170	0.8820
PFM	0.1310	0.930	0.6530	0.5470	0.7100	0.9670	0.6830	1.0000	0.9730	0.1780
Arms LM	0.2080	0.2420	0.7770	0.630	0.9280	0.3950	0.9230	0.4550	0.4980	0.6880
Trunk LM	0.7130	0.3860	0.5700	0.5840	0.4640	0.5890	0.7010	0.4390	0.0410	0.3990
Legs LM	0.1650	0.9920	0.9340	0.8440	0.7990	0.6050	0.9050	0.6580	0.6730	0.5350
Total LM	0.3040	0.2440	0.7130	0.6730	0.6310	0.4560	0.8770	0.4700	0.5040	0.4050
PLM	0.6130	0.7240	0.9950	0.4860	0.6710	0.8940	0.7070	0.9540	0.9990	0.1000

BMI: body mass index; QTDT: quantitative transmission disequilibrium test; FM: fat mass; LM: lean mass; PFM: percentage of FM; and PLM: percentage of LM. BMI and body composition phenotype values are adjusted for age. Bold numbers indicate significant values .