Research Article
Influence of Rapid Urbanization on Thyroid Autoimmune Disease in China
Table 4
Genetic risk estimation for 4 SNPs and TPOAb.
| | SNP | Genotypes | SY frequencies N (%) | OR (95%) | NJ frequencies N (%) | OR (95%) | | TPOAb‒ | TPOAb+ | TPOAb‒ | TPOAb+ |
| | SNP1 (rs9277555) | AA | 236 (27.5) | 14 (17.9) | 1 (ref) | 297 (25.9) | 41 (24.3) | 1 (ref) | | AG | 432 (50.4) | 49 (62.8) | 1.912 (1.034, 3.536) | 568 (49.6) | 85 (50.3) | 1.084 (0.728, 1.614) | | GG | 189 (22.1) | 15 (19.2) | 1.338 (0.630, 2.841) | 280 (24.5) | 43 (25.4) | 1.112 (0.704, 1.759) | | SNP2 (rs11675434) | CC | 427 (48.6) | 34 (42.5) | 1 (ref) | 547 (47.9) | 68 (40.2) | 1 (ref) | | CT | 384 (43.7) | 30 (37.5) | 0.981 (0.589, 1.634) | 481 (42.1) | 75 (44.4) | 1.254 (0.884, 1.780) | | TT | 68 (7.7) | 16 (20.0) | 2.955 (1.547, 5.643) | 115 (10.1) | 26 (15.4) | 1.819 (1.109, 2.982) | | SNP3 (rs301799) | TT | 585 (66.3) | 49 (62.8) | 1 (ref) | 820 (71.4) | 110 (65.1) | 1 (ref) | | CT | 278 (31.5) | 27 (34.6) | 1.160 (0.710, 1.895) | 292 (25.4) | 47 (27.8) | 1.200 (0.832, 1.731) | | CC | 20 (2.3) | 2 (2.6) | 1.194 (0.271, 5.258) | 36 (3.1) | 12 (7.1) | 2.485 (1.255, 4.919) | | SNP4 (rs3094228) | AA | 600 (69.6) | 50 (66.7) | 1 (ref) | 832 (72.8) | 129 (76.3) | 1 (ref) | | AG | 244 (28.3) | 24 (32.0) | 1.180 (0.710, 1.964) | 282 (24.7) | 37 (21.9) | 0.846 (0.573, 1.249) | | GG | 18 (2.1) | 1 (1.3) | 0.667 (0.087, 5.098) | 29 (2.5) | 3 (1.8) | 0.667 (0.200, 2.222) |
|
|
