Research Article

Insulin-induced Lipohypertrophy in Patients with Type 1 Diabetes Mellitus Treated with an Insulin Pump

Table 3

Univariate and multivariate models for risk factors of advanced LH based on the authorial scale (6–8 points).

VariableOR perUnivariateMultivariate
OR (95% CI)OR (95% CI)

Age1 year1.04 (0.98–1.09)0.18
Male sexNo/Yes1.29 (0.52–3.24)0.58
BMIkg/m21.22 (1.06–1.43)0.0071.14 (0.96–1.37)0.15
Diabetes duration1 year1.05 (0.99–1.12)0.081.06 (0.99–1.14)0.13
Duration of CSII1 year0.99 (0.90–1.09)0.82
Regular changing of infusion sitesNo/Yes0.67 (0.17–2.28)0.53
Changing infusion set every 3 day or more frequentlyNo/Yes0.84 (0.33–2.11)0.72
Length of cannula ≥9 mmNo/Yes4.01 (1.52–11.39)0.0073.44 (1.11–11.74)0.038
HbA1c%1.11 (0.76–1.61)0.57
Dose of insulin >0.7 IU/kgNo/Yes3.89 (1.47–10.96)0.0084.81 (1.53–17.22)0.010
Dose of insulinIU1.03 (1.004–1.06)0.03

In the multivariate logistic regression model the variables with -value <0.10 based on univariate logistic models were included (except for daily insulin dose because of including dose of insulin per kg body weight). For abbreviations see Tables 1 and 2.