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Vitamin D Binding Protein and Vitamin D Levels

Call for Papers

Vitamin D deficiency is common in the general world population. Since circulating 25(OH) D levels vary among different ethnic populations, it is difficult to define vitamin D deficiency. Vitamin D binding protein (DBP) is the major transport protein for vitamin D metabolites in plasma, and 88–93% of 25(OH) D in the circulation is bound to DBP. Recent studies have found that serum DBP levels are decreased in type 1 diabetes, chronic liver, and renal diseases. It is unclear whether a change in levels of DBP would have any effect on concentrations of vitamin D metabolites, as DBP circulates at a higher level than its ligands. It is also unclear the etiology behind changes in DBP levels and its relationship to PTH and 25(OH) D levels.

We invite original research articles as well as review articles that seek to define the relationship of DBP and vitamin D levels in different disease conditions in human and animal models. We are interested in articles that explore free and bioavailable vitamin D levels, its relation to levels of vitamin D metabolites, and its association with risks of various diseases including cancer, osteoporosis, and diabetes. Potential topics include, but are not limited to:

  • DBP levels in various disease conditions
  • DBP levels in different ethnic populations
  • Genetic variations of DBP and vitamin D metabolites
  • Factors affecting free and bioavailable vitamin D levels
  • The role of DBP during growth and pregnancy
  • Associations of DBP and vitamin D levels with cancer, osteoporosis, diabetes, and other diseases

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:

Manuscript DueFriday, 24 January 2014
First Round of ReviewsFriday, 18 April 2014
Publication DateFriday, 13 June 2014

Lead Guest Editor

  • Xiangbing Wang, Division of Endocrinology, Metabolism and Nutrition, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08093, USA

Guest Editors

  • Arthur Santora, Merck, Rahway, NJ 07065, USA
  • Sue A. Shapses, Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USA
  • Zhongjian Xie, Institute of Metabolism and Endocrinology, Central South University, Changsha, Hunan 410083, China