International Journal of Endocrinology

Type 2 Diabetes Mellitus and Macrovascular Complications


Status
Published

1Zhejiang University, Hangzhou, China

2Harvard University, Boston, USA

3Rambam Medical Center, Haifa, Israel

4University of Illinois, Chicago, USA


Type 2 Diabetes Mellitus and Macrovascular Complications

Description

The number of people with type 2 diabetes mellitus (T2DM) has been increasing worldwide due to aging, urbanization, and dietary and lifestyle changes. Chronic hyperglycemia in patients with T2DM causes serious complications. Macrovascular complications, mainly including cardiovascular and cerebrovascular diseases, are the most common complications and the major cause of mortality and morbidity in patients with T2DM.

In recent years, there are several advances in this filed. Diabetes patients usually have hyperglycemia, hyperlipidemia, and insulin resistance; all of them are risk factors for macrovascular diseases. PKCs, RAGE, and ROS may mediate the effects of hyperglycemia and hyperlipidemia on cardiovascular systems. Knockout of PKCβ, RAGE, and Nox1 could attenuate the development of atherosclerosis in diabetic mice. To mimic endothelial or macrophage insulin resistance, insulin receptor was specifically knocked out in endothelial cells or macrophages. The development of atherosclerosis was accelerated in endothelial insulin receptor knockout mice and the plaque was more unstable in macrophages insulin receptor knockout mice. Look AHEAD trial and the Italian Diabetes and Exercise Study indicate that lifestyle management significantly improves physical fitness, A1c, and coronary heart disease (CHD) risk factors. Weight loss surgery, especially bariatric surgery, could result in weight loss, A1c improvement, and CVD risk factor improvement. Furthermore, data are available about the effect of glucose-lowering therapies on cardiovascular risk in patients with T2DM. In addition, clinic trials have demonstrated that with comprehensive management of CVD risk factors such as lowering blood glucose, smoking rate, and total cholesterol as well as blood pressure mortality rates from macrovascular complications have been declining steadily in some countries.

We invite investigators to submit original research articles and review articles aimed at exploring the prevalence of macrovascular complications in T2DM, the relationship of CVD risks and macrovascular outcome, the molecular pathways regulating macrovascular pathology, findings in human and animal that can reduce macrovascular complications, and new information in clinic trial.

Potential topics include but are not limited to the following:

  • Impact of genetic background on macrovascular complications
  • Molecular pathways and macrovascular pathology
  • Chronic inflammation and endothelial dysfunction
  • Epidemiology of macrovascular complications
  • Risks for macrovascular complications
  • Obesity and macrovascular diseases
  • Contribution of excise in macrovascular complications
  • Diet and macrovascular complications
  • Weight loss surgery and macrovascular complications
  • DPP-4 inhibitor and incretin on macrovascular events
  • Hypoglycemia, fluctuation of blood glucose, and cardiovascular and cerebrovascular diseases
  • Specific glucose-control strategies on macrovascular outcomes
  • Predictive equitation for macrovascular complication

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 4301461
  • - Editorial

Type 2 Diabetes Mellitus and Macrovascular Complications

Peng-Fei Shan | Qian Li | ... | Gui-fen Qiang
  • Special Issue
  • - Volume 2017
  • - Article ID 1537213
  • - Review Article

Does HbA1c Level Have Clinical Implications in Diabetic Patients Undergoing Coronary Artery Bypass Grafting? A Systematic Review and Meta-Analysis

Jia Zheng | Jing Cheng | ... | Xinhua Xiao
  • Special Issue
  • - Volume 2017
  • - Article ID 9501792
  • - Research Article

Hydrogen Sulfide Inhibits High Glucose-Induced sFlt-1 Production via Decreasing ADAM17 Expression in 3T3-L1 Adipocytes

Tian-xiao Hu | Gang Wang | ... | Jing Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 9620513
  • - Research Article

Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China

Xiao-Hong Pang | Jue Han | ... | Peng-Fei Shan
  • Special Issue
  • - Volume 2017
  • - Article ID 2383651
  • - Research Article

The Validity and Reliability between Automated Oscillometric Measurement of Ankle-Brachial Index and Standard Measurement by Eco-Doppler in Diabetic Patients with or without Diabetic Foot

Jing Ma | Min Liu | ... | Xingwu Ran
  • Special Issue
  • - Volume 2017
  • - Article ID 5262560
  • - Research Article

Nonalcoholic Fatty Liver Disease and Associated Metabolic Risks of Hypertension in Type 2 Diabetes: A Cross-Sectional Community-Based Study

Xiaoying Ding | Ying Xu | ... | Yongde Peng
  • Special Issue
  • - Volume 2017
  • - Article ID 7938216
  • - Research Article

Metabolomic Signature of Coronary Artery Disease in Type 2 Diabetes Mellitus

Bernd Stratmann | Katrin Richter | ... | Rui Wang-Sattler
  • Special Issue
  • - Volume 2016
  • - Article ID 8483405
  • - Research Article

Gender Differences in Risks of Coronary Heart Disease and Stroke in Patients with Type 2 Diabetes Mellitus and Their Association with Metabolic Syndrome in China

Mei-Fang Yao | Jie He | ... | Peng-Fei Shan
  • Special Issue
  • - Volume 2016
  • - Article ID 6704851
  • - Research Article

Early Intervention of Didang Decoction on MLCK Signaling Pathways in Vascular Endothelial Cells of Type 2 Diabetic Rats

Shoujiao Ye | Zhenqiang Song | ... | Bai Chang
International Journal of Endocrinology
 Journal metrics
Acceptance rate35%
Submission to final decision48 days
Acceptance to publication46 days
CiteScore3.500
Impact Factor2.299
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