Divergence of AMP Deaminase in the Ice Worm Mesenchytraeus solifugus (Annelida, Clitellata, Enchytraeidae)

Table 3

Abundant ice worm-specific amino acid substitutions. pa is the random probability of a directional bias equal to or greater than that observed (calculated using the two-tail binomial distribution). L, H, and S are, respectively, loop, 𝛼-helix and 𝛽-sheet; i, internal; e, external.

Substitutions	Forward	Reverse	Position	Region	pa
V→I	4	0	267,349,515,520	Le-Hi-Le-Hi	0.125
A→S	2	0	121,345	Le-Hi	0.5
L→F	0	2	304,362	Si-Li	0.5
K→D	2	0	141,268	He-Le	0.5
L→S	1	0	77	He	—
K→S	1	0	132	Se	—
P→S	1	0	323	Le	—
I→L	1	0	273	Hi	—
F→L	1	0	304	Si	—
D→T	1	0	122	Le	—
M→T	1	0	317	Li	—
P→A	1	0	430	Hi	—
C→V	1	0	472	Hi	—
N→K	1	0	216	Si	—
K→E	1	0	188	Li	—
Y→F	1	0	342	Li	—
D→Q	1	0	272	Hi	—
A→L	1	0	263	Le	—