Table of Contents
International Journal of Evolutionary Biology
Volume 2011 (2011), Article ID 970768, 11 pages
http://dx.doi.org/10.4061/2011/970768
Research Article

Ectopic Gene Conversions in the Genome of Ten Hemiascomycete Yeast Species

Département de Biologie et Centre de Recherche Avancée en Génomique Environnementale, Université d'Ottawa, 30 Marie Curie, Ottawa, ON, Canada K1N 6N5

Received 21 July 2010; Revised 18 September 2010; Accepted 15 October 2010

Academic Editor: Hiromi Nishida

Copyright © 2011 Robert T. Morris and Guy Drouin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We characterized ectopic gene conversions in the genome of ten hemiascomycete yeast species. Of the ten species, three diverged prior to the whole genome duplication (WGD) event present in the yeast lineage and seven diverged after it. We analyzed gene conversions from three separate datasets: paralogs from the three pre-WGD species, paralogs from the seven post-WGD species, and common ohnologs from the seven post-WGD species. Gene conversions have similar lengths and frequency and occur between sequences having similar degrees of divergence, in paralogs from pre- and post-WGD species. However, the sequences of ohnologs are both more divergent and less frequently converted than those of paralogs. This likely reflects the fact that ohnologs are more often found on different chromosomes and are evolving under stronger selective pressures than paralogs. Our results also show that ectopic gene conversions tend to occur more frequently between closely linked genes. They also suggest that the mechanisms responsible for the loss of introns in S. cerevisiae are probably also involved in the gene 3'-end gene conversion bias observed between the paralogs of this species.