Evolution of the FGF Gene Family

Table 1

FGF domain containing protein sequences used in this study. For each species the accession number of all the proteins found are given, as well as orthology when well supported in phylogenetic reconstructions. Best blastP hit are given when no clear orthologu relationships was found.

Species	Accession number	Description	Database	Best blastP hit accession	Best blastP hit name	Orthology
Hydra magnipapillata	XP_002165496.1	Predicted: similar to fibroblast growth factor homologous factor 4	Genbank	NP_001180935.1	Fibroblast growth factor 12 (Macaca mulatta)
	XP_002164870.1	Predicted: similar to fibroblast growth factor 24	Genbank			FGF8/17/18
	XP_002166704.1	Predicted: similar to fibroblast growth factor 1B, partial	Genbank			FGF1/2
	XP_002170051.1	Predicted: similar to Fibroblast growth factor 14 (Hydra magnipapillata)	Genbank	XP_001094679.1	Predicted: fibroblast growth factor 20 (Macaca mulatta)
Lottia gigantea	fgenesh2_pg.C_sca_; 110000014		JGI	XP_002643284.1	EGL-17 (Caenorhabditis briggsae)
	fgenesh2_pg.C_sca_; 16000265		JGI	XP_003455818.1	Predicted: fibroblast growth factor 20-like (Oreochromis niloticus)
Capitella teleta	fgeneshl_pg.C_scaffold_; 1200000001		JGI	XP_002922927.1	Predicted: fibroblast growth factor 18-like (Ailuropoda melanoleuca)
Trichinella spiralis	XP_003370033	Fibroblast growth factor 20	Genbank	NP_001098209.1	Fibroblast growth factor 20a (Oryzias latipes)
	EFV50493.1	Fibroblast growth factor 18	Genbank			FGF8/17/18
Brugia malayi	XP_001894505.1	Fibroblast growth factor family protein	Genbank			FGF9/16/20
	XP_001899322.1	Fibroblast growth factor family protein	Genbank			FGF8/17/18
Apis mellifera	XP_623927.2	Predicted: hypothetical protein LOC551529	Genbank			FGF1/2
	XP_001120331.2	Predicted: hypothetical protein LOC724469	Genbank			BNL
	XP_003695580.1	Predicted: fibroblast growth factor 18-like	Genbank			FGF8/17/18
Harpegnathos saltator	EFN80858.1	Hypothetical protein EAI_11890	Genbank	XP_003399646.1	Predicted: hypothetical protein LOCI00646960 (Bombus terrestris)
	EFN81752.1	Fibroblast growth factor 18	Genbank			FGF8/17/18
	EFN88402.1	Heparin-binding growth factor 1	Genbank			FGF1/2
Pediculus humanus subsp. corporis	EEB17861.1	Fibroblast growth factor, putative	Genbank	XP_003243356.1	Predicted: hypothetical protein LOC100572243 (Acyrthosiphon pisum)
	EEB19433.1	Heparin-binding growth factor 1 precursor, putative	Genbank			FGF1/2
	EEB18362.1	Conserved hypothetical protein	Genbank	XP_002431100.1	Predicted: hypothetical protein LOC 100569010 (Acyrthosiphon pisum)
Ixodes scapu laris	XP_002433492.1	Hypothetical protein IscW_ISCW015993	Genbank	XP_003203489.1	Predicted: glia-activating factor-like (Meleagris gallopavo)
	XP_002400933.1	Heparin-binding growth factor, putative	Genbank			FGF1/2
Daphnia pulex	EFX75093.1	Hypothetical protein DAPPUDRAFT_; 108237	Genbank	XP_003243356.1	Predicted: hypothetical protein LOC; 100572243 (Acyrthosiphon pisum)
	EFX86332.1	Hypothetical protein DAPPUDKAFT_; 98099	Genbank	XP_001635198.1	Predicted protein (Nematostella vectensis)
Saccoglossus kowalevskii	ADB22412.1	Fibroblast growth factor 8/17/18 protein	Genbank			FGF8/17/18
	ADB22409.1	Hypothetical protein	Genbank	XP_799351.2
	ACY92516.1	Fgf-Sk1protein	Genbank	NP_001233192.1
	ACY92517.1	FGF9-like protein	Genbank			FGF9/16/20
	ACY92515.1	FGF13-like protein	Genbank			FGF9/16/20
	ADB22411.1	Fibroblast growth factor 20-like protein	Genbank			FGF9/16/20
Oikopleura dioica	CBY43668.1	Unnamed protein product	Genbank	XP_003441021.1	Predicted: fibroblast growth factor 14-like (Oreochromis niloticus)
	CBY37156.1	Unnamed protein product	Genbank			FGF11/12/13/14
	CBY40156.1	Unnamed protein product	Genbank			FGF11/12/13/14
	CBY12333.1	Unnamed protein product	Genbank			FGF9/16/20
	CBY34733.1	Unnamed protein product	Genbank	NP_001007762.1	Keratinocyte growth factor precursor (Danio rerio)
	CBY23701.1	Unnamed protein product	Genbank	XP_002594626.1	Hypothetical protein BRAFLDRAFT_149779 (Branchiostoma floridae)