Chromatin Evolution and Molecular Drive in Speciation

Table 1

Hybrid incompatibility genes mentioned in the current paper. Whether data concerning these genes are consistent or inconsistent with the current hypothesis is indicated.

Gene	Species	Phenotype^a	Comment	Consistent	Reference
Lhr (HP3)	Drosophila melanogaster/D. simulans	F1-L	Interaction with heterochromatin proteins	Yes	[23, 24]
Hmr	D. melanogaster/D. simulans	F1-L, FS	Chromatin-binding	Yes	[28]
zhr (1.688)	D. melanogaster/D. simulans	F1-L	Centromeric repetitive DNA	Yes	[37, 41]
hlx	D. melanogaster/D. simulans	BC-L	Centromeric repetitive DNA?	Yes	[61]
OdsH	D. melanogaster/D. simulans	F1, BC-MS	Heterochromatin-binding	Yes	[66, 72]
Nup160	D. melanogaster/D. simulans	BC-L, FS	Centromeric heterochromatin-binding?	Yes	[78, 80]
Nup96	D. melanogaster/D. simulans	BC-L	Centromeric heterochromatin-binding?	Yes	[79]
Prdm9	Mus m. musculus/M. m. domesticus	F1, BC-MS	Histone methylation	Yes	[98]
Sxa	M. m. musculus/M. m. domesticus; M. musculus/M. spretus	F1, BC-XY, MS	Heterochromatic repetitive DNA?	Yes	[103, 104]
tmy	D. simulans/D. mauritiana	BC-MS	Not separable from the gene causing meiotic drive	Yes	[120]
Ovd	D. p. pseudoobscura/D. p. bogotana	F1, BC-MS	Chromatin-binding; also causing meiotic drive	Yes	[122]
Cent728	Mimulus guttatus/M. nasutus	F1, BC-FMD	Centromeric repetitive DNA	Yes	[130]
JYalpha	D. melanogaster/D. simulans	BC-MS	Transposition	No	[133]

^aF₁: hybrid; BC: (equivalent to) backcross; L: lethal; FS: female sterile; MS: male sterile; XY: XY dissociation; FMD: female meiotic drive.