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International Journal of Evolutionary Biology
Volume 2012, Article ID 310278, 14 pages
Research Article

New Insights into Ligand-Receptor Pairing and Coevolution of Relaxin Family Peptides and Their Receptors in Teleosts

1Department of Biology, University of Winnipeg, Winnipeg, MB, Canada R3B 2E9
2Department of Biology, Faculty of Science, University of Utrecht, 3584 CH Utrecht, The Netherlands

Received 30 March 2012; Revised 7 June 2012; Accepted 15 June 2012

Academic Editor: Frédéric Brunet

Copyright © 2012 Sara Good et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table A1. Expression studies describing expression of relaxin family ligands and their receptors in mammals and teleosts.

Table A2: Summary of the orthologous/paralogous relationships of the genes coding for relaxin family peptides and their receptors in humans, the gnathostome ancestor (post 2R ancestor), zebrafish and the remaining teleosts for which whole genome sequencing data is available.

Table A3. Results of the site model of codon specific selection in mammalian and teleost RLN/INSL genes.

Table A4. Results of the site model of codon specific selection in mammalian and teleost RXFP genes.

Table A5. Results of the analyses using the branch-site model A of Zhang et al. [30] on relaxin family orthologues, specifying either teleosts or mammals as the foreground branch on which the alternate (alt) hypothesis of positive selection will be compared to the null model (ω=1, fixed).

Table A6. Primers used to determine the relative expression of rln/insl and rxfp genes in zebrafish.

Figure A1. Histograms presenting the proportion of sites showing evidence of positive selection in the branch-site model comparing teleost versus mammalian gene.

Figure A2. Relative expression of relaxin ligand genes in zebrafish tissues.

Figure A3. Relative expression of relaxin receptor genes in zebrafish tissues.

  1. Supplementary Materials