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International Journal of Electrochemistry
Volume 2011, Article ID 171389, 11 pages
Research Article

Online Monitoring of Electrochemical Degradation of Paracetamol through a Biomimetic Sensor

1Departamento de Química Analítica, IQ, Universidade Estadual Paulista, 14801-970 Araraquara, SP, Brazil
2Departamento de Química e Física Molecular, IQSC, Universidade de São Paulo, 13560-970 São Carlos, SP, Brazil
3Instituto de Química, Universidade Estadual de Campinas, 13083-970 Campinas, SP, Brazil

Received 22 February 2011; Accepted 19 March 2011

Academic Editor: Bengi Uslu

Copyright © 2011 Mariana Calora Quintino de Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper reports, for the first time, the online monitoring to the electrochemical degradation of the paracetamol using a biomimetic sensor coupled to a Flow Injection Analysis (FIA) system. The electrochemical degradation of the drug was carried out in aqueous medium using a flow-by reactor with a DSA anode. The process efficiency was monitored at real time by the biomimetic sensor constructed by modifying a glassy carbon electrode with a Nafion membrane doped with iron tetrapyridinoporphyrazine (FeTPyPz). Simultaneously, we carried out off-line analysis by liquid chromatography (HPLC) during the experiments in order to validate the proposed system. In addition, to investigate the degradation products of the paracetamol electrolysis, we used the techniques of UPLC/MS and GC/MS.