Electrochemical Detection of Sequence-Specific DNA with the Amplification of Gold Nanoparticles
Figure 5
The histograms of the peak current difference () of adriamycin versus different DNA sequences (1.0 × 10−10 M): (A) noncomplementary sequence, (B) single-base mismatch sequence, (C) complementary sequence. Inset: DPV responses of adriamycin recorded at probe modified electrode (a) and after hybridization with 1.0 × 10−10 M noncomplementary sequence (b); 1.0 × 10−10 M single-base mismatch sequence (c); 1.0 × 10−10 M complementary sequence (d). Accumulation time of adriamycin: 20 min; Hybridization time: 25 min. DPV parameters were the same as in Figure 2(B).
