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International Journal of Electrochemistry
Volume 2011 (2011), Article ID 825790, 11 pages
Review Article

Recent Advances in Electrochemical Glycobiosensing

Bioprocess Measurements Group, Biochemical Science Division, Material Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899, USA

Received 16 March 2011; Accepted 8 April 2011

Academic Editor: Bengi Uslu

Copyright © 2011 Germarie Sánchez-Pomales and Rebecca A. Zangmeister. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Biosensors based on electrochemical transduction mechanisms have recently made advances into the field of glycan analysis. These glyco-biosensors offer simple, rapid, sensitive, and economical approaches to the measurement need for rapid glycan analysis for biomarker detection, cancer and disease diagnostics, and bioprocess monitoring of therapeutic glycoproteins. Although the prevalent methods of glycan analysis (high-performance liquid chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy) provide detailed identification and structural analysis of glycan species, there are significantly few low-cost, rapid glycan assays available for diagnostic and screening applications. Here we review instances in which glyco-biosensors have been used for glycan analysis using a variety of electrochemical transduction mechanisms (e.g., amperometric, potentiometric, impedimetric, and voltammetric), selective binding agents (e.g., lectins and antibodies), and redox species (e.g., enzyme substrates, inorganic, and nanomaterial).