Exploration of Electrochemical Intermediates of the Anticancer Drug Doxorubicin Hydrochloride Using Cyclic Voltammetry and Simulation Studies with an Evaluation for Its Interaction with DNA

Figure 1

Cyclic voltammogram of doxorubicin hydrochloride in aqueous buffer at pH 7.4 on glassy carbon electrode. [Doxorubicin hydrochloride] = 33 μM, [NaCl] = 0.160 M, scan rate = 0.1 , and temperature = 25°C. Inset: plot of cathodic peak current versus square root of scan rate for the two-electron reduction of doxorubicin hydrochloride in aqueous buffer at pH 7.4.