Exploration of Electrochemical Intermediates of the Anticancer Drug Doxorubicin Hydrochloride Using Cyclic Voltammetry and Simulation Studies with an Evaluation for Its Interaction with DNA

Table 1

Variation of peak potentials and formal reduction potential with scan rate for the reduction of doxorubicin hydrochloride in aqueous buffer at pH 7.4 on glassy carbon electrode. [Doxorubicin hydrochloride] = 33 μM, [Hepes buffer] = 15 mM, and [NaCl] = 160 mM and temperature = 25°C.

Scan rate (mVs^−1)	Cathodic peak potential, (mV)	Anodic peak potential, (mV)	Formal reduction potential, (mV)
50	−690 ± 5	−640 ± 5	−665 ± 5
100	−690 ± 5	−640 ± 5	−665 ± 5
200	−690 ± 5	−640 ± 5	−665 ± 5
300	−696 ± 5	−636 ± 5	−666 ± 5
400	−704 ± 5	−634 ± 5	−669 ± 5
500	−706 ± 5	−630 ± 5	−668 ± 5
600	−708 ± 5	−614 ± 5	−661 ± 5
1000	−710 ± 5	−610 ± 5	−660 ± 5