A New Approach for the Determination of Benzocaine and Procaine in Pharmaceuticals by Single-Sweep Polarography

Table 1

Brief description of some methods for determination of BC and PC.

Anesthetic	Method	Linear range	LOQ	LOD	Objects analyzed	References
PC	HPLC-UV	0.05 – 5.0 μg /mL	0.05 μg/mL	–	human plasma	[6]
PC	HPLC – MS – ESI	10 – 100 ng / mL	10.0 ng/mL	0.100 ng/mL	serum of human blood	[7]
BC	SP	10 – 25 μg / L	–	–		[8]
PC	DPV	3 – 50 μМ	–	0.91 μМ	commercial pharmaceutical samples	[22]
PC	DSWV	1 – 250 μМ	1.35 μМ	0.4 μМ	commercial pharmaceutical samples	[22]
BC		1.0 – 100 μМ	0.83 μM	0.25 μM	pharmaceutical products	[23]
BC	FIA–AD; HPLC–AD	0.2 – 100; 0.2 – 100 μM	–; –	0.19; 0.20 μM		[24]
BC	BIA–AD	0.1 – 8 μM	–	0.0302 μM		[25]
BC	DPV; SWV	0.1 – 400 μM; 0.4 – 200 μM	0.27 μM; 0.32 μM	0.08 μM; 0.1 μM	pharmaceutical samples, spiked urine samples	[26]

BIA–AD: batch injection analysis with amperometric detection; DPV: differential pulse voltammetry; DSWV: differential square wave voltammetry; FIA–AD – flow injection analysis with amperometric detection; HPLC: AD with amperometric detection; HPLC–MS–ESI: high-performance liquid chromatography–tandem mass spectrometry with electrospray ionization; HPLC-UV: high-performance liquid chromatography with ultraviolet detection; SP: spectrophotometry.