Selective Electrochemical Determination of Etoposide Using a Molecularly Imprinted Overoxidized Polypyrrole Coated Glassy Carbon Electrode

Table 2

Effect of metabolites on the differential pulse voltammetric response at the MIP/GCE sensor in biological human fluids.

Biological fluid	Metabolite	Concentration	Signal increase	RSD ()
		(10^-6M)	()	n=3
Plasma	ETP Quinone	2	0.39	0.38
		5	0.41	0.11
		8	0.99	0.42
	ETP Catechol	2	0.92	0.60
		5	1.01	0.46
		8	1.04	1.21
Serum	ETP Quinone	2	0.88	0.55
		5	0.96	1.21
		8	0.99	0.29
	ETP Catechol	2	0.68	0.73
		5	1.74	0.43
		8	1.90	0.28
Urine	ETP Quinone	2	0.44	0.61
		5	0.58	1.42
		8	0.61	0.78
	ETP Catechol	2	0.93	0.81
		5	1.23	1.09
		8	1.31	0.91

Spiked concentration to 10.0 mL of 5.0×10⁻⁶ M ETP solution.
Percent increase of analytical response following the addition of metabolite.