International Journal of Genomics

International Journal of Genomics / 2002 / Article

Conference Review | Open Access

Volume 3 |Article ID 120813 | https://doi.org/10.1002/cfg.192

Olaf Wolkenhauer, Carla Möller-Levet, Fatima Sanchez-Cabo, "The Curse of Normalization", International Journal of Genomics, vol. 3, Article ID 120813, 5 pages, 2002. https://doi.org/10.1002/cfg.192

The Curse of Normalization

Received31 May 2002
Accepted12 Jun 2002

Abstract

Despite its enormous promise to further our understanding of cellular processes involved in the regulation of gene expression, microarray technology generates data for which statistical pre-processing has become a necessity before any interpretation of data can begin. The process by which we distinguish (and remove) non-biological variation from biological variation is called normalization. With a multitude of experimental designs, techniques and technologies influencing the acquisition of data, numerous approaches to normalization have been proposed in the literature. The purpose of this short review is not to add to the many suggestions that have been made, but to discuss some of the difficulties we encounter when analysing microarray data.

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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