International Journal of Genomics

International Journal of Genomics / 2002 / Article

Conference review | Open Access

Volume 3 |Article ID 540942 |

Mohamed Zouine, Quentin Sculo, Bernard Labedan, "Correct Assignment of Homology is Crucial When Genomics Meets Molecular Evolution", International Journal of Genomics, vol. 3, Article ID 540942, 6 pages, 2002.

Correct Assignment of Homology is Crucial When Genomics Meets Molecular Evolution

Received09 Sep 2002
Accepted07 Oct 2002


Pertinent evolutionary studies are based on a correct use of homology terms such as paralogues, metalogues and orthologues. Such crucial concepts have been applied to intragenomic and intergenomic analyses. A further requisite is a proper definition of what is a structural segment of homology. Such segments are called modules to reflect that they play a role in the mechanism of combinational construction of a gene from ready-made basic components. Since identifying a module is operationally equivalent to determining the ancestor to this gene segment, it becomes possible to track back protein history and genome evolution. Such studies underline the importance of two fundamental processes, gene duplication and gene fusion. Moreover, grouping the closest orthologues in families is a pertinent way to reconstruct a genomic tree for all available prokaryotes.

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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