Conference Review | Open Access
Ulf Landegren, Fredrik Dahl, Mats Nilsson, Simon Fredriksson, Johan Banér, Mats Gullberg, Jonas Jarvius, Sigrun Gustafsdottir, Ola Söderberg, Olle Ericsson, Johan Stenberg, Edith Schallmeiner, "Padlock and Proximity Probes for In Situ and Array-Based Analyses: Tools for the Post-Genomic Era", International Journal of Genomics, vol. 4, Article ID 392168, 6 pages, 2003. https://doi.org/10.1002/cfg.326
Padlock and Proximity Probes for In Situ and Array-Based Analyses: Tools for the Post-Genomic Era
Highly specific high-throughput assays will be required to take full advantage of the accumulating information about the macromolecular composition of cells and tissues, in order to characterize biological systems in health and disease. We discuss the general problem of detection specificity and present the approach our group has taken, involving the reformatting of analogue biological information to digital reporter segments of genetic information via a series of DNA ligation assays. The assays enable extensive, coordinated analyses of the numbers and locations of genes, transcripts and protein.
Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.