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Comparative and Functional Genomics
Volume 6, Issue 7-8, Pages 345-356
http://dx.doi.org/10.1002/cfg.492
Research article

In Silico Analysis for Transcription Factors With Zn(II)2C6 Binuclear Cluster DNA-Binding Domains in Candida albicans

1Departamento de Bioquímica y Biología Molecular, Universitat de València, Burjassot, Valencia 46100, Spain
2Departamento de Microbiología y Ecología, Facultad de Farmacia, Universitat de València, Avda. Vicent Andrés i Estellés s/n, Burjassot, Valencia 46100, Spain

Received 3 March 2005; Revised 26 May 2005; Accepted 5 September 2005

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A total of 6047 open reading frames in the Candida albicans genome were screened for Zn(II)2C6-type zinc cluster proteins (or binuclear cluster proteins) involved in DNA recognition. These fungal proteins are transcription regulators of genes involved in a wide range of cellular processes, including metabolism of different compounds such as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell wall architecture, etc. The selection criteria used in the sequence analysis were the presence of the CysX2CysX6CysX5-16CysX2CysX6-8Cys motif and a putative nuclear localization signal. Using this approach, 70 putative Zn(II)2C6 transcription factors have been found in the genome of C. albicans.