A total of 6047 open reading frames in the Candida albicans genome were screened for
Zn(II)2C6-type zinc cluster proteins (or binuclear cluster proteins) involved in DNA
recognition. These fungal proteins are transcription regulators of genes involved in a
wide range of cellular processes, including metabolism of different compounds such
as sugars or amino acids, as well as multi-drug resistance, control of meiosis, cell
wall architecture, etc. The selection criteria used in the sequence analysis were the
presence of the CysX2CysX6CysX5-16CysX2CysX6-8Cys motif and a putative nuclear localization signal. Using this approach, 70 putative Zn(II)2C6 transcription factors have been found in the genome of C. albicans.