Research Article | Open Access
Luke Hakes, David L. Robertson, Stephen G. Oliver, Simon C. Lovell, "Protein Interactions from Complexes: A Structural Perspective", International Journal of Genomics, vol. 2007, Article ID 049356, 5 pages, 2007. https://doi.org/10.1155/2007/49356
Protein Interactions from Complexes: A Structural Perspective
By combining crystallographic information with protein-interaction data obtained through traditional experimental means, this paper determines the most appropriate method for generating protein-interaction networks that incorporate data derived from protein complexes. We propose that a combined method should be considered; in which complexes composed of five chains or less are decomposed using the matrix model, whereas the spoke model is used to derive pairwise interactions for those with six chains or more. The results presented here should improve the accuracy and relevance of studies investigating the topology of protein-interaction networks.
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Copyright © 2007 Luke Hakes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.