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Comparative and Functional Genomics
Volume 2007 (2007), Article ID 57513, 13 pages
Review Article

The Progress on Genetic Analysis of Nasopharyngeal Carcinoma

1Center for Molecular Biology of Oral Diseases, College of Dentistry, Graduate College, UIC Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA
2Guanghua School & Research Institute of Stomatology, Sun Yat-Sen University, Guangzhou 510055, China
3Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
4Department of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
5Xinhua Hospital, Shanghai Children's Medical Center, Shanghai Jiaotong University, Shanghai 200127, China
6Department of Oral & Maxillofacial Surgery, The Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510120, China
7Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA

Received 20 November 2007; Accepted 9 December 2007

Academic Editor: W. Zhang

Copyright © 2007 Xiaofeng Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world, but is one of the most common cancers in Southeast Asia. Both genetic and environmental factors contribute to the tumorigenesis of NPC, most notably the consumption of certain salted food items and Epstein-Barr virus infection. This review will focus on the current progress of the genetic analysis of NPC (genetic susceptibilities and somatic alterations). We will review the current advances in genomic technologies and their shaping of the future direction of NPC research.